209735

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142947..143452 Replicon chromosome
Accession NZ_CP079712
Organism Pseudomonas aeruginosa strain PAO1-UW

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag KXE08_RS00660 Protein ID WP_003083773.1
Coordinates 142947..143228 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag KXE08_RS00665 Protein ID WP_003112628.1
Coordinates 143225..143452 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXE08_RS00635 (KXE08_00635) 138198..139547 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
KXE08_RS00640 (KXE08_00640) 139596..140282 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
KXE08_RS00645 (KXE08_00645) 140383..141117 + 735 WP_003115036.1 GntR family transcriptional regulator -
KXE08_RS00650 (KXE08_00650) 141297..141707 + 411 WP_003101225.1 aegerolysin family protein -
KXE08_RS00655 (KXE08_00655) 141739..142647 - 909 WP_003083769.1 LysR family transcriptional regulator -
KXE08_RS00660 (KXE08_00660) 142947..143228 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
KXE08_RS00665 (KXE08_00665) 143225..143452 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
KXE08_RS00670 (KXE08_00670) 143628..144248 - 621 WP_003101226.1 hypothetical protein -
KXE08_RS00675 (KXE08_00675) 144349..144849 + 501 WP_003112629.1 LEA type 2 family protein -
KXE08_RS00680 (KXE08_00680) 144922..145263 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
KXE08_RS00685 (KXE08_00685) 145345..146772 - 1428 WP_003083784.1 GABA permease -
KXE08_RS00690 (KXE08_00690) 146941..148434 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T209735 WP_003083773.1 NZ_CP079712:c143228-142947 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T209735 NZ_CP104288:270653-270955 [Stenotrophomonas maltophilia]
ATGGCTATCAAGAAGAAAGTTGAACTCGAAGCATTTGATGTGGCCGAACACCTTCATACACCGAAGGAAATGGCGGCCTA
TCTCGATGCATGCATCGAAGAAAGCGACGGCGATTCGGCATTCATCGCCAAGGCGCTGGGCGATATCGCGCGTACCCAAG
GGATGAGCAAGGTCGCACGTGCGGCGGGCCTGTCGCGGGAGAGTCTGTATCGTGCCCTGTCTGGCGAGCGCAGCCCTGAT
TTCTCGACCATCCTGAAGGTGACTCGTGCCCTGGGTGTGCGCCTGCATGCCAGCGCTGCATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT209735 WP_003112628.1 NZ_CP079712:c143452-143225 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT209735 NZ_CP104288:270307-270612 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCTGGTGATCACCGCTATCTGGCGGATGGCGTTTCTGAATTGCGTATCGATG
CAGGACCCGGTTACCGCGTGTACTACACCCAGCGGGGCAGGCAGTTGGTGATTCTTCTGGTCGGAGGCGACAAGGGTTCG
CAACAGCGCGATATAGAGAAGGCCAAGGAGATTGCGCGTGCCCTGCGAGCATCGAACTGGTTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References