Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 2290451..2290955 Replicon chromosome
Accession NC_004757
Organism Nitrosomonas europaea ATCC 19718

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag ALW85_RS10970 Protein ID WP_011112612.1
Coordinates 2290692..2290955 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q82T28
Locus tag ALW85_RS10965 Protein ID WP_011112611.1
Coordinates 2290451..2290702 (-) Length 84 a.a.

Genomic Context

ALW85_RS14220ALW85_RS10935ALW85_RS10955ALW85_RS13740ALW85_RS10985ALW85_RS10990ALW85_RS10940ALW85_RS10945ALW85_RS10950ALW85_RS10960ALW85_RS13745ALW85_RS10965ALW85_RS10970ALW85_RS10975ALW85_RS11005ALW85_RS11010
Location: 2285457..2285603 (147 bp)
Type: Others
Protein ID: WP_158297474.1
Location: 2285699..2287000 (1302 bp)
Type: Others
Protein ID: WP_198407847.1
Location: 2288831..2289037 (207 bp)
Type: Others
Protein ID: WP_041356835.1
Location: 2289234..2289694 (461 bp)
Type: Others
Protein ID: Protein_2117
Location: 2292041..2292427 (387 bp)
Type: Others
Protein ID: WP_041356838.1
Location: 2292427..2292885 (459 bp)
Type: Others
Protein ID: WP_011112615.1
Location: 2287101..2287331 (231 bp)
Type: Others
Protein ID: WP_041356832.1
Location: 2287493..2287999 (507 bp)
Type: Others
Protein ID: WP_041356833.1
Location: 2288019..2288435 (417 bp)
Type: Others
Protein ID: WP_041356834.1
Location: 2289895..2290104 (210 bp)
Type: Others
Protein ID: WP_041357279.1
Location: 2290113..2290355 (243 bp)
Type: Others
Protein ID: WP_198407885.1
Location: 2290451..2290702 (252 bp)
Type: Antitoxin
Protein ID: WP_011112611.1
Location: 2290692..2290955 (264 bp)
Type: Toxin
Protein ID: WP_011112612.1
Location: 2291080..2291274 (195 bp)
Type: Others
Protein ID: WP_041356836.1
Location: 2294322..2294531 (210 bp)
Type: Others
Protein ID: WP_041356839.1
Location: 2294670..2295725 (1056 bp)
Type: Others
Protein ID: WP_011112616.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ALW85_RS142202285457..2285603+147WP_158297474.1hypothetical protein-
ALW85_RS10935 (NE2098)2285699..2287000+1302WP_198407847.1group II intron reverse transcriptase/maturase-
ALW85_RS10940 (RK28_RS10920)2287101..2287331-231WP_041356832.1hypothetical protein-
ALW85_RS10945 (NE2099)2287493..2287999-507WP_041356833.1TIR domain-containing protein-
ALW85_RS10950 (NE2100)2288019..2288435-417WP_041356834.1hypothetical protein-
ALW85_RS10955 (RK28_RS10935)2288831..2289037+207WP_041356835.1hypothetical protein-
ALW85_RS137402289234..2289694+461Protein_2117DDE-type integrase/transposase/recombinase-
ALW85_RS10960 (NE2102)2289895..2290104-210WP_041357279.1BrnA antitoxin family protein-
ALW85_RS137452290113..2290355-243WP_198407885.1BrnT family toxin-
ALW85_RS10965 (NE2103)2290451..2290702-252WP_011112611.1CopG family transcriptional regulatorAntitoxin
ALW85_RS10970 (NE2104)2290692..2290955-264WP_011112612.1BrnT family toxinToxin
ALW85_RS10975 (RK28_RS10955)2291080..2291274-195WP_041356836.1hypothetical protein-
ALW85_RS10985 (NE2106)2292041..2292427+387WP_041356838.1DUF2384 domain-containing protein-
ALW85_RS10990 (NE2107)2292427..2292885+459WP_011112615.1RES family NAD+ phosphorylase-
ALW85_RS11005 (RK28_RS10985)2294322..2294531-210WP_041356839.1addiction module protein-
ALW85_RS11010 (NE2110)2294670..2295725-1056WP_011112616.1Fic family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegron--2284323..22912746951


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9982.43 Da        Isoelectric Point: 5.6792

>T20971 WP_011112612.1 NC_004757:c2290955-2290692 [Nitrosomonas europaea ATCC 19718]
MIAFEFDEAKSQANLLKHGISFVDAQALWNDPRLLEIPAKTEDEPRYLMIGLINGKHWSAVITYRGTNIRLISVRCSRTE
EVTLYES

Download         Length: 264 bp

>T20971 NC_004757:c2290955-2290692 [Nitrosomonas europaea ATCC 19718]
ATGATAGCTTTTGAGTTTGACGAGGCAAAGAGTCAGGCCAATCTTCTGAAACATGGCATCAGCTTTGTTGATGCTCAAGC
ATTATGGAATGACCCAAGATTACTGGAGATTCCCGCAAAAACAGAAGATGAACCACGATACCTTATGATAGGGCTGATTA
ACGGCAAACACTGGTCTGCCGTTATCACTTACAGGGGTACAAATATCAGGCTTATTTCCGTTCGTTGCTCACGTACCGAG
GAGGTGACACTATATGAAAGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9515.87 Da        Isoelectric Point: 7.0158

>AT20971 WP_011112611.1 NC_004757:c2290702-2290451 [Nitrosomonas europaea ATCC 19718]
MKAKDFEQQFDEGVDITASLDLSKAKRVLQEQKRVNVDFPTWMIESLDREAEKLGVTRQSIIKVWLAERLEKAALTHPSS
GTR

Download         Length: 252 bp

>AT20971 NC_004757:c2290702-2290451 [Nitrosomonas europaea ATCC 19718]
ATGAAAGCTAAAGATTTTGAACAGCAGTTTGACGAAGGCGTTGATATTACTGCTTCGCTGGATTTGTCAAAGGCAAAGCG
CGTATTGCAAGAGCAAAAACGTGTCAATGTCGATTTCCCAACGTGGATGATTGAGTCTCTTGACCGGGAAGCTGAAAAGC
TTGGTGTGACCAGGCAATCTATCATTAAGGTGTGGCTTGCCGAACGCCTCGAAAAGGCTGCTCTAACCCATCCATCAAGC
GGGACGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBQ82T28

References