Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2663567..2664083 Replicon chromosome
Accession NZ_CP079673
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC29_CMC309MPCH

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag KW562_RS12875 Protein ID WP_004178374.1
Coordinates 2663799..2664083 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KW562_RS12870 Protein ID WP_002886901.1
Coordinates 2663567..2663809 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW562_RS12855 (2659595) 2659595..2660335 + 741 WP_002886899.1 KDGP aldolase family protein -
KW562_RS12860 (2660402) 2660402..2661556 + 1155 WP_004178372.1 lactonase family protein -
KW562_RS12865 (2661579) 2661579..2663489 + 1911 WP_004178373.1 PRD domain-containing protein -
KW562_RS12870 (2663567) 2663567..2663809 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KW562_RS12875 (2663799) 2663799..2664083 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KW562_RS12880 (2664087) 2664087..2664551 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KW562_RS12885 (2664792) 2664792..2666930 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KW562_RS12890 (2667287) 2667287..2668030 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KW562_RS12895 (2668033) 2668033..2668206 - 174 WP_032408826.1 hypothetical protein -
KW562_RS12900 (2668336) 2668336..2668599 + 264 WP_228985702.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T209691 WP_004178374.1 NZ_CP079673:2663799-2664083 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T209691 NZ_CP104274:1901928-1902182 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT209691 WP_002886901.1 NZ_CP079673:2663567-2663809 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT209691 NZ_CP104274:1901680-1901931 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References