Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 58669..59405 | Replicon | plasmid pCMC387MPCH_P2 |
Accession | NZ_CP079670 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC28_CMC387MPCH |
Toxin (Protein)
Gene name | tacT | Uniprot ID | L7SZ15 |
Locus tag | KW561_RS28215 | Protein ID | WP_003026803.1 |
Coordinates | 58923..59405 (+) | Length | 161 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | L7SZ29 |
Locus tag | KW561_RS28210 | Protein ID | WP_003026799.1 |
Coordinates | 58669..58935 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KW561_RS28165 (KW561_28150) | 54731..55093 | - | 363 | WP_004152100.1 | arsenite efflux transporter metallochaperone ArsD | - |
KW561_RS28170 (KW561_28155) | 55143..55493 | - | 351 | WP_004152101.1 | As(III)-sensing metalloregulatory transcriptional repressor ArsR | - |
KW561_RS28175 (KW561_28160) | 55851..56120 | + | 270 | WP_004152102.1 | hypothetical protein | - |
KW561_RS28180 (KW561_28165) | 56108..56683 | + | 576 | WP_004152103.1 | hypothetical protein | - |
KW561_RS28185 (KW561_28170) | 56714..57208 | + | 495 | WP_004152104.1 | DNA-binding protein | - |
KW561_RS28190 (KW561_28175) | 57252..57620 | + | 369 | WP_004152105.1 | hypothetical protein | - |
KW561_RS28195 (KW561_28180) | 57654..57857 | + | 204 | WP_004152106.1 | HHA domain-containing protein | - |
KW561_RS28200 (KW561_28185) | 57906..58163 | + | 258 | WP_004152107.1 | hypothetical protein | - |
KW561_RS28205 (KW561_28190) | 58239..58493 | + | 255 | WP_004152108.1 | hypothetical protein | - |
KW561_RS28210 (KW561_28195) | 58669..58935 | + | 267 | WP_003026799.1 | DUF1778 domain-containing protein | Antitoxin |
KW561_RS28215 (KW561_28200) | 58923..59405 | + | 483 | WP_003026803.1 | GNAT family N-acetyltransferase | Toxin |
KW561_RS28220 (KW561_28205) | 59617..60963 | + | 1347 | WP_020314316.1 | ISNCY family transposase | - |
KW561_RS29380 | 61124..61255 | + | 132 | WP_004218042.1 | hypothetical protein | - |
KW561_RS28225 (KW561_28210) | 61464..62629 | - | 1166 | Protein_67 | IS3 family transposase | - |
KW561_RS28230 (KW561_28215) | 62806..63768 | - | 963 | WP_004152113.1 | zinc metalloprotease HtpX | - |
KW561_RS28235 (KW561_28220) | 63755..64243 | - | 489 | WP_004152114.1 | phosphate-starvation-inducible PsiE family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | catA1 | - | 1..211813 | 211813 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 161 a.a. Molecular weight: 17353.97 Da Isoelectric Point: 9.5822
>T209678 WP_003026803.1 NZ_CP079670:58923-59405 [Klebsiella pneumoniae subsp. pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP
Download Length: 483 bp
>T209678 NZ_CP104254:615817-615999 [Pseudomonas aeruginosa]
ATGCGGAGTAGGGAAGTGATTGATTTGCTGTTGGAGGATGGCTGGTATGAAGTGGCGGTGAAAGGTAGCCACCACCAGTT
CAAACATCCTTCAAAGCCTGGAAAGGTGACGGTTCAACATCCGTCCTCGACGATACCGAAAGGAACCCTGAACAACATAC
TGAAACAAGCCGGCCTCAAGTGA
ATGCGGAGTAGGGAAGTGATTGATTTGCTGTTGGAGGATGGCTGGTATGAAGTGGCGGTGAAAGGTAGCCACCACCAGTT
CAAACATCCTTCAAAGCCTGGAAAGGTGACGGTTCAACATCCGTCCTCGACGATACCGAAAGGAACCCTGAACAACATAC
TGAAACAAGCCGGCCTCAAGTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10147.59 Da Isoelectric Point: 4.5256
>AT209678 WP_003026799.1 NZ_CP079670:58669-58935 [Klebsiella pneumoniae subsp. pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV
Download Length: 267 bp
>AT209678 NZ_CP104254:616027-616431 [Pseudomonas aeruginosa]
ATGAAATTCCCCGTGGTGTTACACAAAGACCCTGATTCTGACTATGGCGTGACTGTGCCCGATGTGCCGGGTTGCTTCTC
TGCCGGCGCTACGGTGTCCGAGGCCCTGGCCAATGTAGAAGAGGCGCTGGCCTTGCACTTCGAAGGCTTGGTTACGGACG
GCGAAGAGCTACCCCAGCCGCAGGACGTTGACGCCCATATGAAGAATCCGGACTTCGAAGGTGGCGTATGGGCGGTGGTT
GACTTCGACGTGACCCCGTACCTGGGCAAGGCCGTACGCTTTAATGCGACGCTCCCGGAACACCTTCTGCAGCGGATCGA
TGAGCGCGTGAAGGTGGATAAGCGCTATCAGTCTCGGTCGGGCTTTCTGGCAACAGCGGCGATGCGCGAACTGTCAGTGG
CGTGA
ATGAAATTCCCCGTGGTGTTACACAAAGACCCTGATTCTGACTATGGCGTGACTGTGCCCGATGTGCCGGGTTGCTTCTC
TGCCGGCGCTACGGTGTCCGAGGCCCTGGCCAATGTAGAAGAGGCGCTGGCCTTGCACTTCGAAGGCTTGGTTACGGACG
GCGAAGAGCTACCCCAGCCGCAGGACGTTGACGCCCATATGAAGAATCCGGACTTCGAAGGTGGCGTATGGGCGGTGGTT
GACTTCGACGTGACCCCGTACCTGGGCAAGGCCGTACGCTTTAATGCGACGCTCCCGGAACACCTTCTGCAGCGGATCGA
TGAGCGCGTGAAGGTGGATAAGCGCTATCAGTCTCGGTCGGGCTTTCTGGCAACAGCGGCGATGCGCGAACTGTCAGTGG
CGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0J2GNW6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1Q8YL66 |