Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /RES-TIGR02293 |
Location | 167689..168599 | Replicon | plasmid pCMC387MPCH_P1 |
Accession | NZ_CP079669 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC28_CMC387MPCH |
Toxin (Protein)
Gene name | - | Uniprot ID | A0A5Q9LR54 |
Locus tag | KW561_RS27290 | Protein ID | WP_004181896.1 |
Coordinates | 168129..168599 (+) | Length | 157 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A0A2J4RLY9 |
Locus tag | KW561_RS27285 | Protein ID | WP_004181895.1 |
Coordinates | 167689..168132 (+) | Length | 148 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KW561_RS27265 (KW561_27250) | 162966..163673 | + | 708 | WP_062826779.1 | hypothetical protein | - |
KW561_RS27270 (KW561_27255) | 163678..164709 | + | 1032 | WP_170856552.1 | CRISPR-associated protein Csf2 | - |
KW561_RS27275 (KW561_27260) | 165895..166317 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
KW561_RS27280 (KW561_27265) | 166317..167588 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
KW561_RS27285 (KW561_27270) | 167689..168132 | + | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
KW561_RS27290 (KW561_27275) | 168129..168599 | + | 471 | WP_004181896.1 | RES family NAD+ phosphorylase | Toxin |
KW561_RS27295 (KW561_27280) | 168709..168969 | - | 261 | WP_004026352.1 | hypothetical protein | - |
KW561_RS27300 (KW561_27285) | 169540..170721 | - | 1182 | WP_004883380.1 | IS481 family transposase | - |
KW561_RS27305 (KW561_27290) | 170793..170951 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
KW561_RS27310 (KW561_27295) | 171554..172528 | + | 975 | WP_043907013.1 | hypothetical protein | - |
KW561_RS27315 (KW561_27300) | 172726..173103 | - | 378 | WP_004181901.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | blaCTX-M-15 / aac(6')-Ib / blaTEM-1A / tet(D) / dfrA14 / qnrB1 / blaOXA-1 / aac(6')-Ib-cr / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 | - | 1..286022 | 286022 | |
- | flank | IS/Tn | - | - | 169540..170721 | 1181 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17549.81 Da Isoelectric Point: 4.6155
>T209676 WP_004181896.1 NZ_CP079669:168129-168599 [Klebsiella pneumoniae subsp. pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T209676 NZ_CP104217:87090-87623 [Burkholderia gladioli]
ATGATCCTCACGCCGCTGCAGGACATCACGGCCTATCGCATGCACGTGCCTAAGTGGGCTGTGGCGCCCACCAGTGGCGC
TGGCGCGGCCCGGGCCGGCGGCCGGGCGAACCGGATCGGCACGCCGGCGCTGTATCTGGCGCTCGAGGTGGCCACCGCCG
TGGCCGAGTATCAGCAGCTGTCGCCCCTGCTGCCGCCCGGCACGCTGGTGAGCTATCGGGTCCAGGCGACGCCCGTGGTC
GATTTCACCGGCGGTTTTCGCGCGGATCTCTGGCCACCTCTGTGGGAATCCTTCTTCTGCGACTGGCGCCGCGACTGGTT
CAACGCGCGGATCGAGCCGCCCAGCTGGGTGCTGGGCGACGAGGCGATCGCCGCCGGCGCCAAGGGCATCCTGTTTCGCT
CGACGCAGGCTGCGGGCGGCACGAACCTGGTGCTGTTCGTGGACCAGCTGGCGGAGGGCGATCGCCTGGACGTGAACGAC
CCGGCCTGTGCTCTGCCACGCAACCAGGTCTCCTGGGGCGAGCCGACCGCCTGA
ATGATCCTCACGCCGCTGCAGGACATCACGGCCTATCGCATGCACGTGCCTAAGTGGGCTGTGGCGCCCACCAGTGGCGC
TGGCGCGGCCCGGGCCGGCGGCCGGGCGAACCGGATCGGCACGCCGGCGCTGTATCTGGCGCTCGAGGTGGCCACCGCCG
TGGCCGAGTATCAGCAGCTGTCGCCCCTGCTGCCGCCCGGCACGCTGGTGAGCTATCGGGTCCAGGCGACGCCCGTGGTC
GATTTCACCGGCGGTTTTCGCGCGGATCTCTGGCCACCTCTGTGGGAATCCTTCTTCTGCGACTGGCGCCGCGACTGGTT
CAACGCGCGGATCGAGCCGCCCAGCTGGGTGCTGGGCGACGAGGCGATCGCCGCCGGCGCCAAGGGCATCCTGTTTCGCT
CGACGCAGGCTGCGGGCGGCACGAACCTGGTGCTGTTCGTGGACCAGCTGGCGGAGGGCGATCGCCTGGACGTGAACGAC
CCGGCCTGTGCTCTGCCACGCAACCAGGTCTCCTGGGGCGAGCCGACCGCCTGA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT209676 WP_004181895.1 NZ_CP079669:167689-168132 [Klebsiella pneumoniae subsp. pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT209676 NZ_CP104217:86668-87093 [Burkholderia gladioli]
ATGAGCACCCTCGCACCAGCCCGAGAACCCGCCGCGCCAGCCTGCGGCCCGGCCCCGGCAAGCTTTGATGCATTCCTGAG
TGCGTTGCGCGAGCCGGACACGACGGCTCCCGTGCTGTCGGCCAGGCGTTACGTGGCGGCCCTGAACATCGACTTGCAGA
CGCTCGCCGACCAGGCTCACGTCCACCGAAACACCGTCGCCCGCGCGCCGCAGTCGGCAAGCGTCCAGCAGTTCCTGCGC
GAGGCGATCCGCGTGATCCGCGCCGCGACGGATCTGTCGGGCGACGTCCAGCGCGCGCTGTTCTGGTATCGCAACGAGCC
GCTTGCCGTGTTTGACTACCAGACCGCCGAAACCCTGGTGTCGGCCGGCCGCGCCGATGACGTGGTGCGCTATGTGGCGT
CGCTCGAGGCGGGCGCCGCCGGATGA
ATGAGCACCCTCGCACCAGCCCGAGAACCCGCCGCGCCAGCCTGCGGCCCGGCCCCGGCAAGCTTTGATGCATTCCTGAG
TGCGTTGCGCGAGCCGGACACGACGGCTCCCGTGCTGTCGGCCAGGCGTTACGTGGCGGCCCTGAACATCGACTTGCAGA
CGCTCGCCGACCAGGCTCACGTCCACCGAAACACCGTCGCCCGCGCGCCGCAGTCGGCAAGCGTCCAGCAGTTCCTGCGC
GAGGCGATCCGCGTGATCCGCGCCGCGACGGATCTGTCGGGCGACGTCCAGCGCGCGCTGTTCTGGTATCGCAACGAGCC
GCTTGCCGTGTTTGACTACCAGACCGCCGAAACCCTGGTGTCGGCCGGCCGCGCCGATGACGTGGTGCGCTATGTGGCGT
CGCTCGAGGCGGGCGCCGCCGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5Q9LR54 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J4RLY9 |