Detailed information of TA system TA209673

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5052057..5053738
• Replicon: chromosome
• Accession: NZ_CP079668
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC28_CMC387MPCH

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: KW561_RS24495
• Protein ID: WP_004178299.1
• Coordinates: 5052057..5052974 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: KW561_RS24500
• Protein ID: WP_004177809.1
• Coordinates: 5052980..5053738 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KW561_RS24475 (5047363)	5047363..5048883	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
KW561_RS24480 (5048880)	5048880..5049878	+	999	WP_002885172.1	ribose ABC transporter permease	-
KW561_RS24485 (5049909)	5049909..5050850	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
KW561_RS24490 (5050925)	5050925..5051932	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
KW561_RS24495 (5052057)	5052057..5052974	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KW561_RS24500 (5052980)	5052980..5053738	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KW561_RS24505 (5053824)	5053824..5054552	-	729	WP_004178298.1	response regulator transcription factor	-
KW561_RS24510 (5054825)	5054825..5056972	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
KW561_RS24515 (5057202)	5057202..5057888	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T209673 WP_004178299.1 NZ_CP079668:c5052974-5052057 [Klebsiella pneumoniae subsp. pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T209673 NZ_CP104215:c2003667-2003380 [Burkholderia gladioli]
TTGCTGCGCTCCAGTGAATTCACAAACTGGCTTTCCAGCCTGCGTGATCAGCGCGGCAAAGCCCGAATCGCCGCACGCCT
GATCAGTGCCCAGCTAGGCAATTTTGGCGAGTACCGTGTGATAGGCGAAGGCGTCCGCGAAATGAAGGTCGACTTCGGGC
CGGGTTATCGCATCTACTATGTCCGTCGCGCCGAGATCGTCTATGTCCTTCTCTGCGGTGGCGATAAATCTACACAGAAA
AAAGACATCAAGCGCGCGCTCCAGATGGCGCGCGAACTGAAGGAGTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT209673 WP_004177809.1 NZ_CP079668:c5053738-5052980 [Klebsiella pneumoniae subsp. pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT209673 NZ_CP104215:c2003376-2003092 [Burkholderia gladioli]
ATGCCCGATTACGCCGAATTCGATGCGGCCGACTATCTCGACAATGACGAAACCGTGGCGGAATTTCTCGCGGTTGCGGC
CGAGGATCCCGATCCCGCAGTGTTCCTTGCTGCCGTGGCCGCTGTCGCACGCGCGCGCGGGATGACCAAGGTGGCGTCGG
AAGCCGGCCTTGGACGGGTCACCTTGCACAAGGCGCTGACACCTGGCGCTCACCCTCGATATGAGACCGTGCAGAAGATC
CTGCGCTCGCTGGGCCTTCGCATGACCTTCACCGTCGCCCACTGA

Structures

Antitoxin

• AlphaFold DB: A6TH05