Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Hha-TomB/- |
| Location | 4191218..4191837 | Replicon | chromosome |
| Accession | NZ_CP079668 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC28_CMC387MPCH | ||
Toxin (Protein)
| Gene name | Hha | Uniprot ID | R8WYV2 |
| Locus tag | KW561_RS20430 | Protein ID | WP_002892050.1 |
| Coordinates | 4191619..4191837 (+) | Length | 73 a.a. |
Antitoxin (Protein)
| Gene name | TomB | Uniprot ID | J2DPF6 |
| Locus tag | KW561_RS20425 | Protein ID | WP_002892066.1 |
| Coordinates | 4191218..4191592 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KW561_RS20415 (4186370) | 4186370..4187563 | + | 1194 | WP_004177236.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
| KW561_RS20420 (4187586) | 4187586..4190732 | + | 3147 | WP_117248583.1 | multidrug efflux RND transporter permease subunit AcrB | - |
| KW561_RS20425 (4191218) | 4191218..4191592 | + | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
| KW561_RS20430 (4191619) | 4191619..4191837 | + | 219 | WP_002892050.1 | HHA domain-containing protein | Toxin |
| KW561_RS20435 (4191996) | 4191996..4192562 | + | 567 | WP_002892030.1 | maltose O-acetyltransferase | - |
| KW561_RS20440 (4192534) | 4192534..4192674 | - | 141 | WP_004147370.1 | hypothetical protein | - |
| KW561_RS20445 (4192695) | 4192695..4193165 | + | 471 | WP_002892026.1 | YlaC family protein | - |
| KW561_RS20450 (4193140) | 4193140..4194591 | - | 1452 | WP_002892023.1 | PLP-dependent aminotransferase family protein | - |
| KW561_RS20455 (4194692) | 4194692..4195390 | + | 699 | WP_004178762.1 | GNAT family protein | - |
| KW561_RS20460 (4195387) | 4195387..4195527 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
| KW561_RS20465 (4195527) | 4195527..4195790 | - | 264 | WP_002892011.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T209670 WP_002892050.1 NZ_CP079668:4191619-4191837 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T209670 NZ_CP104214:c3085452-3084868 [Burkholderia gladioli]
ATGGACGACGCGTTGATCGACGCACGACTGGATTTCCTGCGCGGCTGCGAGCGCCTGAAGGATGTGCTGCGCAGCGGCCA
TACCTCGGGCGGGCGACGCGAGAGCACGGCCGAGCACAGCTGGCGGCTCGCGCTGATGGCGATGGTGCTGATGGATCAAT
TGGGCGAGGTCGACCCCGGCAGGGTGCTCGAGCTCTGCCTGGTGCATGACCTGGGCGAAGCGCTGGGCGGCGACGTGCCG
GCGCCCGAGCAGGCCCCGGGCAGCGACAAGGATGCCGCCGAGCGACGCGACCTGCTGCGCCTCGGCGACGCGCTCGATGC
GCCGATGCGCGAGAGGATCGTCGCGTTGTGGGACGAGTATGCGCGGGCGGCCACGCCGGAAGCACGCGCGGTGAAGGCGC
TCGACAAGATCGAGACGATCCTGCAGCACACGCAGGGCGAGAATCCGCCCGATTTCGACTATGCGTTCAATCTCTCGTAT
GGGCAGGCGCATACGCGCAAGGTGCCGGCGCTGCAGCGGTTTCGCGAGCGCGTCGACGAGGCGACGCGCGAGCGGATGAC
CCGTGCTGGCGGGCCTTCGGGCTGA
ATGGACGACGCGTTGATCGACGCACGACTGGATTTCCTGCGCGGCTGCGAGCGCCTGAAGGATGTGCTGCGCAGCGGCCA
TACCTCGGGCGGGCGACGCGAGAGCACGGCCGAGCACAGCTGGCGGCTCGCGCTGATGGCGATGGTGCTGATGGATCAAT
TGGGCGAGGTCGACCCCGGCAGGGTGCTCGAGCTCTGCCTGGTGCATGACCTGGGCGAAGCGCTGGGCGGCGACGTGCCG
GCGCCCGAGCAGGCCCCGGGCAGCGACAAGGATGCCGCCGAGCGACGCGACCTGCTGCGCCTCGGCGACGCGCTCGATGC
GCCGATGCGCGAGAGGATCGTCGCGTTGTGGGACGAGTATGCGCGGGCGGCCACGCCGGAAGCACGCGCGGTGAAGGCGC
TCGACAAGATCGAGACGATCCTGCAGCACACGCAGGGCGAGAATCCGCCCGATTTCGACTATGCGTTCAATCTCTCGTAT
GGGCAGGCGCATACGCGCAAGGTGCCGGCGCTGCAGCGGTTTCGCGAGCGCGTCGACGAGGCGACGCGCGAGCGGATGAC
CCGTGCTGGCGGGCCTTCGGGCTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT209670 WP_002892066.1 NZ_CP079668:4191218-4191592 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT209670 NZ_CP104214:c3086145-3085555 [Burkholderia gladioli]
ATGAAACCGATATCGTCGAACCAGGCGACGACCACGTCCTTGCCGCCGTCCGCGCTGGCCTGTTCGCCGGGCGCGAGCTT
GCGTCGATGGCGCACGCTGCGCCGGATCAAGCAGGAACATGCGGCGGCGCTGTTCGGCGTATCGCAGTCGACGATATCGC
GCTGGGAAGCCGGCACGCAGGCGGTGTCGCACGAGGAACTGCGGCGCATCGAGGCCTGCTTGTCGGCGCGCCTCGACTCG
GCGGCGGATCGCGCGCTCGAGCGCCTCGTCAGCCATCACACCCGTCCCGTTCATCTCGTCTGCGACCTCACGCACCGGCT
GCTGGCCTGCTCCACGCCGCGAGCCGCGGAGTTCGCGGCGCCGCTGTCGTCGCTGATGGGCGCGTCGCTCTGGCCGTTCG
CGACGGCCGAGATCGTGGCGCGCGAGCAGTCGTTGCGCGATGCGGGCTGGCACGATCATCCGGCGCCCTCGATCGAATTC
GATACCGGGTCCAACGATTCGCCTCAGGTGCCGATTCGTGCGAGCCGCTGCCGCTGGACGCGTTTCACCTTGTCCGACGG
GACGCTGGCGCGCCTGGTCGAGACGCTTTGA
ATGAAACCGATATCGTCGAACCAGGCGACGACCACGTCCTTGCCGCCGTCCGCGCTGGCCTGTTCGCCGGGCGCGAGCTT
GCGTCGATGGCGCACGCTGCGCCGGATCAAGCAGGAACATGCGGCGGCGCTGTTCGGCGTATCGCAGTCGACGATATCGC
GCTGGGAAGCCGGCACGCAGGCGGTGTCGCACGAGGAACTGCGGCGCATCGAGGCCTGCTTGTCGGCGCGCCTCGACTCG
GCGGCGGATCGCGCGCTCGAGCGCCTCGTCAGCCATCACACCCGTCCCGTTCATCTCGTCTGCGACCTCACGCACCGGCT
GCTGGCCTGCTCCACGCCGCGAGCCGCGGAGTTCGCGGCGCCGCTGTCGTCGCTGATGGGCGCGTCGCTCTGGCCGTTCG
CGACGGCCGAGATCGTGGCGCGCGAGCAGTCGTTGCGCGATGCGGGCTGGCACGATCATCCGGCGCCCTCGATCGAATTC
GATACCGGGTCCAACGATTCGCCTCAGGTGCCGATTCGTGCGAGCCGCTGCCGCTGGACGCGTTTCACCTTGTCCGACGG
GACGCTGGCGCGCCTGGTCGAGACGCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2P8K6F2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GJ93 |