Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 1496762..1497386 Replicon chromosome
Accession NC_004757
Organism Nitrosomonas europaea ATCC 19718

Toxin (Protein)


Gene name vapC Uniprot ID Q82UU9
Locus tag ALW85_RS07185 Protein ID WP_011111947.1
Coordinates 1496762..1497166 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q82UU8
Locus tag ALW85_RS07190 Protein ID WP_011111948.1
Coordinates 1497153..1497386 (-) Length 78 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ALW85_RS07170 (NE1370) 1492130..1495783 - 3654 WP_011111944.1 CDP-glycerol glycerophosphotransferase family protein -
ALW85_RS07175 (NE1371) 1496148..1496469 + 322 Protein_1384 type II toxin-antitoxin system RelE/ParE family toxin -
ALW85_RS07180 (NE1372) 1496453..1496731 + 279 WP_011111946.1 helix-turn-helix domain-containing protein -
ALW85_RS07185 (NE1373) 1496762..1497166 - 405 WP_011111947.1 PIN domain-containing protein Toxin
ALW85_RS07190 (NE1374) 1497153..1497386 - 234 WP_011111948.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ALW85_RS07195 (NE1375) 1497622..1497948 + 327 WP_011111949.1 helix-turn-helix domain-containing protein -
ALW85_RS07200 (RK28_RS07195) 1498109..1498351 + 243 WP_041357175.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
ALW85_RS07205 (RK28_RS07200) 1498397..1498585 + 189 WP_143023784.1 hypothetical protein -
ALW85_RS07210 (NE1377) 1498593..1499024 + 432 WP_011111951.1 putative toxin-antitoxin system toxin component, PIN family -
ALW85_RS07215 (NE1378) 1499301..1500344 - 1044 WP_011110833.1 IS481 family transposase -
ALW85_RS07220 (NE1379) 1500454..1500918 - 465 WP_041356758.1 hypothetical protein -
ALW85_RS07225 (NE1380) 1500944..1501282 - 339 WP_011111953.1 STAS-like domain-containing protein -
ALW85_RS07230 (NE1381) 1501279..1502232 - 954 WP_011111954.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1475610..1500344 24734
- flank IS/Tn - - 1499301..1500344 1043


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-116)

Antitoxin

(5-44)


Sequences


Toxin        


Download         Length: 135 a.a.        Molecular weight: 14982.12 Da        Isoelectric Point: 4.4315

>T20967 WP_011111947.1 NC_004757:c1497166-1496762 [Nitrosomonas europaea ATCC 19718]
MKDHSAFLDTNILLYLLSEDETKSVRAENTIAAGGFISVQVLNEFASVARRKLNMSFAEIQEFLSHIRMICSVVPVTVEV
HDQGLRIAEHYGFSIYDALIIAAALSADCTILYSEDMQNSQIIDDRLLIQNPFA

Download         Length: 405 bp

>T20967 NC_004757:c1497166-1496762 [Nitrosomonas europaea ATCC 19718]
ATGAAAGATCATAGTGCTTTTCTGGATACGAATATCCTGCTGTATCTTTTATCCGAAGATGAAACAAAATCTGTTCGGGC
GGAAAACACTATTGCAGCTGGCGGCTTTATCAGTGTTCAGGTGCTCAATGAATTCGCAAGTGTGGCCCGGAGGAAACTGA
ACATGTCCTTTGCTGAAATCCAGGAATTTCTTTCACACATACGCATGATATGTTCCGTAGTGCCGGTTACTGTCGAAGTA
CATGATCAAGGGCTCCGGATAGCGGAACACTATGGATTTTCGATATATGATGCATTGATCATCGCCGCAGCATTATCGGC
TGATTGCACGATCCTTTATTCAGAAGATATGCAGAACAGCCAAATAATTGATGATCGGCTTCTAATTCAAAATCCCTTTG
CTTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8915.30 Da        Isoelectric Point: 8.6580

>AT20967 WP_011111948.1 NC_004757:c1497386-1497153 [Nitrosomonas europaea ATCC 19718]
MQVSKWGNSLAVRLPASVVEILDLKEGDSIEIHVAGARDIEIMKTPEAREILERLRKYRGRLPKDFKFDRLEAHERS

Download         Length: 234 bp

>AT20967 NC_004757:c1497386-1497153 [Nitrosomonas europaea ATCC 19718]
ATGCAGGTTTCAAAATGGGGCAACAGTCTGGCAGTCAGATTACCCGCATCAGTTGTTGAAATACTTGATCTCAAGGAAGG
TGATTCTATTGAAATTCACGTGGCAGGTGCCCGTGACATTGAAATCATGAAAACACCGGAAGCCCGTGAAATCCTTGAAC
GACTGAGAAAATACCGTGGGCGATTACCGAAAGACTTCAAATTTGATCGCCTTGAAGCGCATGAAAGATCATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q82UU9


Antitoxin

Source ID Structure
AlphaFold DB Q82UU8

References