Detailed information of TA system TA209668

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2816444..2818032
• Replicon: chromosome
• Accession: NZ_CP079668
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC28_CMC387MPCH

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KW561_RS13840
• Protein ID: WP_004179815.1
• Coordinates: 2816444..2817766 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KW561_RS13845
• Protein ID: WP_004176198.1
• Coordinates: 2817766..2818032 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KW561_RS13825 (2811500)	2811500..2814001	+	2502	WP_004179823.1	fimbria/pilus outer membrane usher protein	-
KW561_RS13830 (2813989)	2813989..2814993	+	1005	WP_004179822.1	fimbrial protein	-
KW561_RS13835 (2815135)	2815135..2816427	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
KW561_RS13840 (2816444)	2816444..2817766	-	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
KW561_RS13845 (2817766)	2817766..2818032	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KW561_RS13850 (2818298)	2818298..2818624	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
KW561_RS13855 (2818621)	2818621..2819121	-	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
KW561_RS13860 (2819099)	2819099..2820478	-	1380	WP_004179808.1	nucleobase:cation symporter-2 family protein	-
KW561_RS13865 (2820824)	2820824..2821978	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
KW561_RS13870 (2821959)	2821959..2822882	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T209668 WP_004179815.1 NZ_CP079668:c2817766-2816444 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T209668 NZ_CP104209:2559710-2559868 [Empedobacter stercoris]
ATGTACTTTATTGAAAAAACTACTGATTTTGATAAATGGTTTCGTAAGTTAAAAGACTTACGAGCAAAGGCTAAAATTTT
AGTTAGAATTCAAAAATTAGAAAAAGAAGAACACTTTGGAGATTGTGAACCTGTTGGCAATGGAATTCGAGAATTATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT209668 WP_004176198.1 NZ_CP079668:c2818032-2817766 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT209668 NZ_CP104209:2560016-2560300 [Empedobacter stercoris]
ATGGAAACATCAAAATTTGATATAGCCGATTATTTAGATAGTAATGAAATGATTGCTGAATACTTAAATGCAGTCTTAGA
AGATGGTAATGAAAATGAAATCATCACTGCTATTGGAAACATTGCAAAAGCAATTGGAATGACTAAAATAGCAGAAGAAA
CAGGTCTTAGTCGTCCAAGTTTATATAAAGCTTTATCTGATGGTTCAAAACCTCAATTTGGAACTATAATGAAAGTTTTA
AAAGCTGTGGGAGGACAAATACAAGTAAATCCTGTTCAAGCTTAA