Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4198414..4199033 Replicon chromosome
Accession NZ_CP079655
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC27_S471MPC

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KW560_RS20790 Protein ID WP_002892050.1
Coordinates 4198815..4199033 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KW560_RS20785 Protein ID WP_002892066.1
Coordinates 4198414..4198788 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW560_RS20775 (4193566) 4193566..4194759 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KW560_RS20780 (4194782) 4194782..4197928 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KW560_RS20785 (4198414) 4198414..4198788 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KW560_RS20790 (4198815) 4198815..4199033 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KW560_RS20795 (4199196) 4199196..4199762 + 567 WP_002892030.1 maltose O-acetyltransferase -
KW560_RS20800 (4199734) 4199734..4199874 - 141 WP_004147370.1 hypothetical protein -
KW560_RS20805 (4199895) 4199895..4200365 + 471 WP_002892026.1 YlaC family protein -
KW560_RS20810 (4200340) 4200340..4201791 - 1452 WP_064162152.1 PLP-dependent aminotransferase family protein -
KW560_RS20815 (4201892) 4201892..4202590 + 699 WP_004177238.1 GNAT family protein -
KW560_RS20820 (4202587) 4202587..4202727 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KW560_RS20825 (4202727) 4202727..4202990 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T209651 WP_002892050.1 NZ_CP079655:4198815-4199033 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T209651 NZ_CP104206:c2156589-2156395 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGGTATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT209651 WP_002892066.1 NZ_CP079655:4198414-4198788 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT209651 NZ_CP104206:2156218-2156396 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAATTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References