Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1429522..1431061 Replicon chromosome
Accession NC_004757
Organism Nitrosomonas europaea ATCC 19718

Toxin (Protein)


Gene name HipA1 Uniprot ID Q82V03
Locus tag ALW85_RS06810 Protein ID WP_011111888.1
Coordinates 1429522..1430811 (-) Length 430 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag ALW85_RS06815 Protein ID WP_041356737.1
Coordinates 1430801..1431061 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ALW85_RS06780 (NE1303) 1425501..1425992 + 492 WP_011111881.1 VCBS repeat-containing protein -
ALW85_RS06785 (NE1304) 1426056..1426358 - 303 WP_011111882.1 HigA family addiction module antidote protein -
ALW85_RS06790 (NE1305) 1426371..1426649 - 279 WP_011111883.1 type II toxin-antitoxin system RelE/ParE family toxin -
ALW85_RS06795 (NE1306) 1426777..1427103 - 327 WP_011111884.1 type II toxin-antitoxin system PemK/MazF family toxin -
ALW85_RS06800 (NE1307) 1427100..1427324 - 225 WP_041356736.1 antitoxin MazE family protein -
ALW85_RS06805 (NE1308) 1427752..1428162 - 411 WP_011111886.1 pilin -
ALW85_RS13630 (NE1309) 1428787..1429083 - 297 WP_011111887.1 DUF2335 domain-containing protein -
ALW85_RS06810 (NE1310) 1429522..1430811 - 1290 WP_011111888.1 type II toxin-antitoxin system HipA family toxin Toxin
ALW85_RS06815 (NE1311) 1430801..1431061 - 261 WP_041356737.1 helix-turn-helix transcriptional regulator Antitoxin
ALW85_RS06825 (NE1312) 1431744..1431947 - 204 WP_011111890.1 cold-shock protein -
ALW85_RS14180 1432243..1432413 + 171 WP_158297464.1 hypothetical protein -
ALW85_RS06840 (NE1313) 1432854..1433387 - 534 WP_011111891.1 response regulator transcription factor -
ALW85_RS06845 (NE1314) 1433412..1434710 - 1299 WP_041357166.1 HAMP domain-containing histidine kinase -
ALW85_RS06850 (NE1315) 1434927..1435931 - 1005 WP_011111893.1 cytochrome-c peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-102)

Antitoxin

Transcription regulator, HipB-like

(8-65)


Sequences

Toxin        


Download         Length: 430 a.a.        Molecular weight: 47579.46 Da        Isoelectric Point: 6.5641

>T20963 WP_011111888.1 NC_004757:c1430811-1429522 [Nitrosomonas europaea ATCC 19718]
MARELEVWLFAERIGTLALIEDRLNFRYSPDWLSRPDAATLSSSLHLQAESFDDHHTRPFFGGLLPEGQLRRLIAQQFQV
SSQNDFALLDHIGGECAGAVTLLEPGQSLSSPGQGDDVQWLSEEEIVAILDELPHRPMLAGKDGVRLSLAGTQDKLPVVS
DGARIGLPRNGSPSSHILKPAIRTLMDTVTNEGFCLALAEAMQLKPAKSQVHSVLGRQFLLIERYDRVVDAQGQRQRLHQ
EDFCQALGVVPEMKYQNEGGPDLVQCFDLVRRITRPSAPQILRLFDYVIFNALIGNHDAHAKNFSLLYAGKSAILAPFYD
VLSTAIYPTLTPKMAMKIGSKYKFSEVQTRHWDQFSEAVGLGKAQARKRILALAKSMPPTARELQSSREHGFAGHAVVEQ
IVILIEQRCALTVRRLSAPAADMEDETVL

Download         Length: 1290 bp

>T20963 NC_004757:c1430811-1429522 [Nitrosomonas europaea ATCC 19718]
ATGGCGCGTGAGCTGGAAGTCTGGCTGTTCGCCGAACGGATTGGAACCCTGGCCCTGATCGAGGACAGGTTGAATTTCCG
TTACAGCCCGGATTGGCTCTCACGCCCAGATGCAGCGACCCTCTCCAGCTCACTGCATCTGCAAGCAGAATCATTCGACG
ATCACCACACGCGGCCCTTCTTTGGGGGACTTTTGCCAGAGGGGCAACTCCGGCGCCTCATTGCACAGCAATTTCAGGTG
TCGAGCCAGAATGATTTTGCGTTGCTCGATCACATCGGTGGGGAGTGTGCCGGGGCTGTTACCTTGCTGGAGCCAGGGCA
GTCGTTGTCCAGTCCTGGGCAAGGCGACGACGTTCAGTGGCTGAGCGAGGAAGAGATTGTTGCCATTCTCGATGAACTGC
CACATCGGCCGATGTTAGCCGGCAAGGATGGCGTGCGGCTCTCACTAGCGGGCACTCAAGACAAACTGCCGGTGGTGTCC
GATGGCGCCCGGATCGGTCTGCCGAGAAATGGATCGCCCAGCTCACATATCTTGAAGCCCGCCATCCGTACCCTGATGGA
CACGGTCACCAACGAAGGCTTCTGTCTGGCGTTGGCTGAAGCCATGCAGCTCAAGCCAGCGAAGTCACAGGTGCATTCCG
TGTTGGGGCGACAGTTCCTGCTGATCGAGCGCTACGACCGGGTGGTCGATGCACAAGGCCAGCGGCAGCGCCTGCACCAA
GAGGACTTTTGCCAGGCGCTGGGCGTGGTGCCGGAAATGAAGTACCAGAACGAAGGCGGCCCGGATCTGGTGCAATGTTT
CGATCTGGTTCGGCGCATCACGCGGCCCAGCGCACCACAGATCCTGCGCTTGTTCGACTATGTGATCTTCAACGCGCTGA
TCGGCAATCATGACGCGCATGCCAAGAATTTCTCACTGCTGTATGCGGGTAAGTCTGCCATCCTGGCGCCGTTCTACGAC
GTGCTGTCGACGGCGATCTATCCGACTCTGACGCCCAAGATGGCGATGAAAATCGGCAGCAAGTACAAATTCAGCGAAGT
ACAGACACGGCACTGGGACCAATTTTCTGAAGCTGTTGGCCTTGGCAAGGCGCAGGCCAGAAAGCGGATTCTGGCCTTGG
CAAAGTCGATGCCGCCGACGGCGCGTGAGCTTCAGTCCAGCCGTGAGCATGGCTTTGCTGGCCATGCCGTGGTTGAGCAA
ATTGTGATCTTGATCGAGCAACGCTGTGCCCTGACAGTACGAAGGCTCAGTGCGCCCGCTGCTGACATGGAGGATGAGAC
TGTCTTATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9001.19 Da        Isoelectric Point: 6.4574

>AT20963 WP_041356737.1 NC_004757:c1431061-1430801 [Nitrosomonas europaea ATCC 19718]
MSSIRTTEQLGDALRAARKQLGLTQPQLALAAGVGVRFIVDLEAGKPTLRLENVLRVIDALGGALQITGLSSSDSENHPE
GNQHGA

Download         Length: 261 bp

>AT20963 NC_004757:c1431061-1430801 [Nitrosomonas europaea ATCC 19718]
ATGAGTTCCATACGAACCACAGAACAACTCGGTGACGCACTGCGTGCTGCACGCAAACAGCTGGGCTTAACACAGCCCCA
GTTGGCTTTGGCGGCAGGGGTTGGTGTGCGCTTCATCGTCGACCTTGAAGCAGGCAAGCCCACTCTGCGTCTGGAAAACG
TGCTGCGCGTGATCGACGCGTTGGGTGGAGCGCTCCAAATCACCGGCTTGTCATCCTCAGACTCCGAAAATCACCCTGAG
GGCAACCAGCATGGCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q82V03

Antitoxin

Source ID Structure

References