Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4876952..4877468 Replicon chromosome
Accession NZ_CP079642
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC22_AI1646MC

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KW558_RS23960 Protein ID WP_040216106.1
Coordinates 4876952..4877236 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KW558_RS23965 Protein ID WP_064162488.1
Coordinates 4877226..4877468 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW558_RS23935 (4872369) 4872369..4872632 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
KW558_RS23940 (4872762) 4872762..4872935 + 174 WP_032425422.1 hypothetical protein -
KW558_RS23945 (4872938) 4872938..4873681 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KW558_RS23950 (4874038) 4874038..4876176 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KW558_RS23955 (4876484) 4876484..4876948 + 465 WP_064162487.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KW558_RS23960 (4876952) 4876952..4877236 - 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KW558_RS23965 (4877226) 4877226..4877468 - 243 WP_064162488.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KW558_RS23970 (4877546) 4877546..4879456 - 1911 WP_023325426.1 PRD domain-containing protein -
KW558_RS23975 (4879479) 4879479..4880633 - 1155 WP_064162489.1 lactonase family protein -
KW558_RS23980 (4880700) 4880700..4881440 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T209615 WP_040216106.1 NZ_CP079642:c4877236-4876952 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T209615 NZ_CP104170:c4641300-4640890 [Pseudomonas aeruginosa]
ATGCTCAAGTTCATGCTTGATACCAACATCTGCATCTTCACCATCAAAAACCGCCCGCAAGAGGTGCGCGAGGCGTTCCT
GCGCCACCACGACCAGATGTGCATCAGCACCGTGACGCTGATGGAGCTGATCTACGGCGCAGAGAAGTCCTCGAACCCCT
CGCGCAATCTTGCGGACGTGGAAGGCTTCGCTGCTCGTCTGGAGGTGCTCAAGTACGACCAGGAAGCTGCCGCCCACACC
GGCCAGCTCCGCGCTGAACTGGCCCGCCTCGGCAAGCAAATCGGCCCCTATGACCAGATGATCGCCGGGCACGCCCGCTC
TCAGGGCCTGATCGTGGTCACCAATAACCGCCGCGAGTTCGACCGCGTACCCGGCTTGAGAGTTGAGGATTGGGTCACCC
CAATCGTATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9059.57 Da        Isoelectric Point: 6.3340

>AT209615 WP_064162488.1 NZ_CP079642:c4877468-4877226 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT209615 NZ_CP104170:c4641530-4641300 [Pseudomonas aeruginosa]
GTGGAACAAGGTTCTGTTTTTCAGAGCAATCGTAGCCAGGCCGTAAGACTGCCCAAGGCCGTCGCGCTTCCTGATGACGT
TAAGCGTGTGGATGTGGTCGCTGTGGGGCGCGCCAGAATCATCACGCCTGCCGGCGAGTCTTGGGATAGCTGGTTCGATA
GCGAGGGCGTTACTGCCGACTTTATGGCAGAGCGTGAACAGCCTGCCGATCAGGAGCGCGAGACTTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References