Detailed information of TA system TA209602

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 790959..791616
• Replicon: chromosome
• Accession: NZ_CP079642
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC22_AI1646MC

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KW558_RS03930
• Protein ID: WP_040245400.1
• Coordinates: 791206..791616 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: KW558_RS03925
• Protein ID: WP_002916312.1
• Coordinates: 790959..791225 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KW558_RS03900 (786115)	786115..787548	-	1434	WP_002916322.1	6-phospho-beta-glucosidase BglA	-
KW558_RS03905 (787667)	787667..788395	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
KW558_RS03910 (788445)	788445..788756	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
KW558_RS03915 (788920)	788920..789579	+	660	WP_048334397.1	hemolysin III family protein	-
KW558_RS03920 (789730)	789730..790713	-	984	WP_032430613.1	tRNA-modifying protein YgfZ	-
KW558_RS03925 (790959)	790959..791225	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
KW558_RS03930 (791206)	791206..791616	+	411	WP_040245400.1	protein YgfX	Toxin
KW558_RS03935 (791623)	791623..792144	-	522	WP_002916308.1	flavodoxin FldB	-
KW558_RS03940 (792245)	792245..793141	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
KW558_RS03945 (793164)	793164..793877	+	714	WP_048290928.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
KW558_RS03950 (793883)	793883..795616	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16035.83 Da
• Isoelectric Point: 11.4778

>T209602 WP_040245400.1 NZ_CP079642:791206-791616 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T209602 NZ_CP104158:2464312-2464722 [Rhizobium tropici]
ATGTATCTGATCGATACCAATATCATTTCTGAAGCGCGTCGCGGCACTATCGAAGCGATATCCTGGCTGCGCATAGCCGA
CCCATCGACCGTCTATCTCAGCGTCATCACACTCGGCGAAGTCATGCGCGGGATCGCCCTTAAGCGAAGGACCGATCCAC
GCGCCGCCGCACATCTGGAAGAATGGCTGCGCAAGCTTCGCCACGATCACAGCGGCCGCATCCTGCCCATCACGGACCAA
ATCGCCGTCGAATGGGGCCGCATCTCCGCGCTGCGCCCTCGCGGCGATGCCGACGGGCTGATCGCGGCCACTGCAATCGT
CCATGATCTGATTATCGTTACGCGCAATGTCAGCGATTTTGACGATGCCGGCGTGTCGGTGATCAATCCTTGGGATCAGG
CATCTTACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT209602 WP_002916312.1 NZ_CP079642:790959-791225 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT209602 NZ_CP104158:2464058-2464312 [Rhizobium tropici]
ATGGATTGGCCATTGCAAGACGCCAAGAATCAATTCTCGAAAGTCGTGCAGAAGGCACGCAGCGAAGGTCCGCAAACTGT
GACACTGCGCGGCGAGCGCGCGGCCGTTGTTCTCTCCGCGGAAGACTATGACGCCTTGCGCGCGGGAAAGCCGAGCCTGG
TGGACGATCTGCTATCGGGGCCAGCCTGGGATGATGAACTGGCCGACGCGGTGATAACGCGAGACAAGACCCCAAGCCGG
GATGTCGCCTTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41