Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 961717..963305 | Replicon | plasmid pAI1527P_P1 |
| Accession | NZ_CP079635 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC19_AI1572C | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | KW555_RS26850 | Protein ID | WP_064162061.1 |
| Coordinates | 961717..963039 (-) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A0H3GXD8 |
| Locus tag | KW555_RS26855 | Protein ID | WP_002904790.1 |
| Coordinates | 963039..963305 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KW555_RS26835 (KW555_26810) | 956773..959274 | + | 2502 | WP_064162059.1 | fimbria/pilus outer membrane usher protein | - |
| KW555_RS26840 (KW555_26815) | 959262..960266 | + | 1005 | WP_064162060.1 | fimbrial protein | - |
| KW555_RS26845 (KW555_26820) | 960408..961700 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
| KW555_RS26850 (KW555_26825) | 961717..963039 | - | 1323 | WP_064162061.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| KW555_RS26855 (KW555_26830) | 963039..963305 | - | 267 | WP_002904790.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| KW555_RS26860 (KW555_26835) | 963571..963897 | - | 327 | WP_064162062.1 | hydroxyisourate hydrolase | - |
| KW555_RS26865 (KW555_26840) | 963894..964394 | - | 501 | WP_064162063.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| KW555_RS26870 (KW555_26845) | 964372..965751 | - | 1380 | WP_040245186.1 | nucleobase:cation symporter-2 family protein | - |
| KW555_RS26875 (KW555_26850) | 966097..967251 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
| KW555_RS26880 (KW555_26855) | 967232..968155 | - | 924 | WP_002904781.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaSHV-28 | fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS / rcsA / kdsA / galU / sodB / mgtC / iroE | 1..1039047 | 1039047 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49155.46 Da Isoelectric Point: 7.5357
>T209581 WP_064162061.1 NZ_CP079635:c963039-961717 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T209581 NZ_CP104139:c864630-864187 [Rhizobium leguminosarum bv. viciae]
GTGACTTTCCTGCTCGACGTCAATGTCCTGATTGCCTTAATCGATCCGGGCCATGTAGCCCATGATGATGCGCACGAATG
GTTCGCGGCGATAGGTCAGAGCGCGTGGGCTAGCTGCCCCATTACCGAAAATGGTGTCATCCGGATTGTCGGCAACCCCA
AATATCCCAACTCTCCCGGTTCACCGTCACTCGTGATGGAAATTGTCCGCAAATTGCGGTCGCTCCCCGGTCACAGTTTT
TGGCCGGACGATGTGAGCCTTGTCGGGTCAGGTGATATCGCTCCCACGAAAATTCTAACGTCGGGGCAGGTAACTGACAC
CTACCTGCTTGCGCTAGCCAAGGCGCGTGGGGGCCAGCTGGCGACATTCGATCGCAAGCTGTCAGCAGCAGCGGTTACAA
GGGGCAATTCTGCCTTGCACCTGATCACCACGAGTAGATCGTGA
GTGACTTTCCTGCTCGACGTCAATGTCCTGATTGCCTTAATCGATCCGGGCCATGTAGCCCATGATGATGCGCACGAATG
GTTCGCGGCGATAGGTCAGAGCGCGTGGGCTAGCTGCCCCATTACCGAAAATGGTGTCATCCGGATTGTCGGCAACCCCA
AATATCCCAACTCTCCCGGTTCACCGTCACTCGTGATGGAAATTGTCCGCAAATTGCGGTCGCTCCCCGGTCACAGTTTT
TGGCCGGACGATGTGAGCCTTGTCGGGTCAGGTGATATCGCTCCCACGAAAATTCTAACGTCGGGGCAGGTAACTGACAC
CTACCTGCTTGCGCTAGCCAAGGCGCGTGGGGGCCAGCTGGCGACATTCGATCGCAAGCTGTCAGCAGCAGCGGTTACAA
GGGGCAATTCTGCCTTGCACCTGATCACCACGAGTAGATCGTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9906.27 Da Isoelectric Point: 8.5912
>AT209581 WP_002904790.1 NZ_CP079635:c963305-963039 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
Download Length: 267 bp
>AT209581 NZ_CP104139:c864854-864627 [Rhizobium leguminosarum bv. viciae]
ATGAGAACGACCTTGGCAATCGACGACGATGTGCTGACCGCAGCAAAAGCGATGGCAACCCAGCAGCACCGGAGCGTCGG
CGAGGTCATTTCTGAGCTGGCGAGACGTTCTCTGCGCCGACCGCCGAGCAGCGGCGAGCGCAACGGCATTCCTCTCCTGT
CAACACGGCCGGATACGCCGCCAGTGACGCTCGAAATCGTGAACGCCATGCGTGACGAAGTGCCGTGA
ATGAGAACGACCTTGGCAATCGACGACGATGTGCTGACCGCAGCAAAAGCGATGGCAACCCAGCAGCACCGGAGCGTCGG
CGAGGTCATTTCTGAGCTGGCGAGACGTTCTCTGCGCCGACCGCCGAGCAGCGGCGAGCGCAACGGCATTCCTCTCCTGT
CAACACGGCCGGATACGCCGCCAGTGACGCTCGAAATCGTGAACGCCATGCGTGACGAAGTGCCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|