Detailed information of TA system TA209572

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3490529..3491186
• Replicon: chromosome
• Accession: NZ_CP079634
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC19_AI1572C

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KW555_RS17020
• Protein ID: WP_040245400.1
• Coordinates: 3490776..3491186 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: KW555_RS17015
• Protein ID: WP_002916312.1
• Coordinates: 3490529..3490795 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KW555_RS16990 (3485685)	3485685..3487118	-	1434	WP_002916322.1	6-phospho-beta-glucosidase BglA	-
KW555_RS16995 (3487237)	3487237..3487965	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
KW555_RS17000 (3488015)	3488015..3488326	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
KW555_RS17005 (3488490)	3488490..3489149	+	660	WP_048334397.1	hemolysin III family protein	-
KW555_RS17010 (3489300)	3489300..3490283	-	984	WP_032430613.1	tRNA-modifying protein YgfZ	-
KW555_RS17015 (3490529)	3490529..3490795	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
KW555_RS17020 (3490776)	3490776..3491186	+	411	WP_040245400.1	protein YgfX	Toxin
KW555_RS17025 (3491193)	3491193..3491714	-	522	WP_002916308.1	flavodoxin FldB	-
KW555_RS17030 (3491815)	3491815..3492711	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
KW555_RS17035 (3492734)	3492734..3493447	+	714	WP_048290928.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
KW555_RS17040 (3493453)	3493453..3495186	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16035.83 Da
• Isoelectric Point: 11.4778

>T209572 WP_040245400.1 NZ_CP079634:3490776-3491186 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T209572 NZ_CP104137:41245-41538 [Sinorhizobium sp. C101]
ATGAGGCTCGTCTGGGCGCGATATGCGCTTGACGATCGCGACACCATCTTCAGTTACATCGAAAGGGAGAATCCGAGGGC
GGCGGTCCACGTCGACGAGGAGATCGTCAGCGCGGTACGTCGTCTGCTTGATTTTCCGGAAAGCGGCCGCCCTGGCCGGA
TTGCCGGAACTCGAGAGCTTGTCATCCCTCGGACCCCCTACATTGCAGCCTACATGGTAATGGAGGATAGAATTCGAATT
CTCCGTGTCCTGCACGGCGCTCAGAAGTGGCCCAGCGAGCTCGACGACGGGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT209572 WP_002916312.1 NZ_CP079634:3490529-3490795 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT209572 NZ_CP104137:40940-41248 [Sinorhizobium sp. C101]
ATGGCTTCAAATGCACTTGTTCAGACTCGAATCGATGCCGAGATCAAAGAGCGCGCCACGGCGGTTTTAGAGAACATGGG
TCTGACGGTCTCGGACGCTGTTCGAATCCTGTTAACTCGGACGGCGAATGAGGGCGCCCTGCCGCTGGAACTCTTCAGCC
ACAGCGAGGCGCACGACGCTTGGTTCCGCGCCAAAGTGCTGCGGGCACTCGAGGATACCCGACCCGACGTCGACGATGCC
GACGCCGATGCGCACTTTCGAGAGCGCCGGGCGGCAGCTTTGCGCAAGGCTGCGGCGGGTGATCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41