Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
| Location | 3034945..3035531 | Replicon | chromosome |
| Accession | NZ_CP079634 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC19_AI1572C | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | W8VD46 |
| Locus tag | KW555_RS14650 | Protein ID | WP_002920800.1 |
| Coordinates | 3035163..3035531 (+) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | W9B1V1 |
| Locus tag | KW555_RS14645 | Protein ID | WP_004174006.1 |
| Coordinates | 3034945..3035166 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KW555_RS14625 (3031102) | 3031102..3032028 | + | 927 | WP_002920807.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
| KW555_RS14630 (3032025) | 3032025..3033302 | + | 1278 | WP_004174005.1 | branched chain amino acid ABC transporter permease LivM | - |
| KW555_RS14635 (3033299) | 3033299..3034066 | + | 768 | WP_002920803.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
| KW555_RS14640 (3034068) | 3034068..3034781 | + | 714 | WP_004145133.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF | - |
| KW555_RS14645 (3034945) | 3034945..3035166 | + | 222 | WP_004174006.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KW555_RS14650 (3035163) | 3035163..3035531 | + | 369 | WP_002920800.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| KW555_RS14655 (3035804) | 3035804..3037120 | + | 1317 | WP_004174008.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
| KW555_RS14660 (3037227) | 3037227..3038114 | + | 888 | WP_002920792.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
| KW555_RS14665 (3038111) | 3038111..3038956 | + | 846 | WP_004174009.1 | sn-glycerol-3-phosphate ABC transporter permease UgpE | - |
| KW555_RS14670 (3038958) | 3038958..3040028 | + | 1071 | WP_004150074.1 | sn-glycerol-3-phosphate import ATP-binding protein UgpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3029931..3040765 | 10834 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13552.92 Da Isoelectric Point: 8.6410
>T209571 WP_002920800.1 NZ_CP079634:3035163-3035531 [Klebsiella pneumoniae subsp. pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG
Download Length: 369 bp
>T209571 NZ_CP104136:c714221-713667 [Sinorhizobium sp. C101]
ATGAGGAAACACAGTCCGCTCGTATCGCGACCCGATCCGGAACCGACGGCGTCGGTCGAGCCGATAACGCTCTGGCGGGC
CTTCGTTCCACGCTGGGCACATATGCCGCTATCCGGCGCGGGTGCTGCTCGCTTCGGTGGCCGCTGGAACCCGATCGGCG
TGCCTGCGATCTATGGCGCGCGCGAGCTTTCCACCGCCTGGGCCGAATACAATCAGGGTTTCGTCCAGCATCCGGCGCTG
ATCGTGCAGCTCGAGTTGCTGGGGGCGAGGCTCGCGGACCTCACGGATGTCAGCCTTCTTGTGGAGCTTGGTGTGGATGA
GGCGATCCATCGCTGCGAATGGCGTGATGCGCTCGACAAGGGCGCGGTGCCGGAGACCCACAGGCTCCAGTCGGAGCTTC
TGGCGCGCGACTTCCATGGGGTGATCTATCCATCCTTCATGTCGCCCGGCGGCACCTGTGTTGCGCTCTGGCGTTGGAAC
GGTCCGCAAGAACCGCGTCTCGGCGTCATCGACCCCGATGGCCGGCTGCCGAAATCGCCCGCCTCATGGGTTTGA
ATGAGGAAACACAGTCCGCTCGTATCGCGACCCGATCCGGAACCGACGGCGTCGGTCGAGCCGATAACGCTCTGGCGGGC
CTTCGTTCCACGCTGGGCACATATGCCGCTATCCGGCGCGGGTGCTGCTCGCTTCGGTGGCCGCTGGAACCCGATCGGCG
TGCCTGCGATCTATGGCGCGCGCGAGCTTTCCACCGCCTGGGCCGAATACAATCAGGGTTTCGTCCAGCATCCGGCGCTG
ATCGTGCAGCTCGAGTTGCTGGGGGCGAGGCTCGCGGACCTCACGGATGTCAGCCTTCTTGTGGAGCTTGGTGTGGATGA
GGCGATCCATCGCTGCGAATGGCGTGATGCGCTCGACAAGGGCGCGGTGCCGGAGACCCACAGGCTCCAGTCGGAGCTTC
TGGCGCGCGACTTCCATGGGGTGATCTATCCATCCTTCATGTCGCCCGGCGGCACCTGTGTTGCGCTCTGGCGTTGGAAC
GGTCCGCAAGAACCGCGTCTCGGCGTCATCGACCCCGATGGCCGGCTGCCGAAATCGCCCGCCTCATGGGTTTGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8151.15 Da Isoelectric Point: 4.7769
>AT209571 WP_004174006.1 NZ_CP079634:3034945-3035166 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK
Download Length: 222 bp
>AT209571 NZ_CP104136:c714599-714228 [Sinorhizobium sp. C101]
ATGATTGCCCTCGATTTCCAGATCCCTGCAGCCCGTTTCGGGGACGATCATTCCCCGTTTCTCTCGGCCCGCCTGGTCGC
CGACCGATTGGGCGTCACCCTCGCCGAACTCGCCAAGCTGATCGGTGTCGCCCGCAATACGCTGACGGCGAAATCCGGCG
CCCGGAAGGTGGACAGCGCCTTGAGCAAGGTCGTCCGCATCCTGGCCATGGCTTCCGAAATGGCGGGCGACGAAGCCCGC
GCCGTCATCTGGTTCAAGCACCAGCCTATTCCCGGCTGGGCCGGCAAGACGGCATTCGACCTGGTCGGTGAAGGCAAGGC
CGACAAGGTGCTCGCCTATCTCGAATCGGTACGCGCCGGCGTCTACGCTTAA
ATGATTGCCCTCGATTTCCAGATCCCTGCAGCCCGTTTCGGGGACGATCATTCCCCGTTTCTCTCGGCCCGCCTGGTCGC
CGACCGATTGGGCGTCACCCTCGCCGAACTCGCCAAGCTGATCGGTGTCGCCCGCAATACGCTGACGGCGAAATCCGGCG
CCCGGAAGGTGGACAGCGCCTTGAGCAAGGTCGTCCGCATCCTGGCCATGGCTTCCGAAATGGCGGGCGACGAAGCCCGC
GCCGTCATCTGGTTCAAGCACCAGCCTATTCCCGGCTGGGCCGGCAAGACGGCATTCGACCTGGTCGGTGAAGGCAAGGC
CGACAAGGTGCTCGCCTATCTCGAATCGGTACGCGCCGGCGTCTACGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GUD1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E5YJY7 |