Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 770567..771069 Replicon chromosome
Accession NC_004757
Organism Nitrosomonas europaea ATCC 19718

Toxin (Protein)


Gene name yoeB Uniprot ID Q82WG5
Locus tag ALW85_RS03725 Protein ID WP_011111332.1
Coordinates 770815..771069 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A837WYN7
Locus tag ALW85_RS03720 Protein ID WP_041356508.1
Coordinates 770567..770818 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ALW85_RS03685 (NE0706) 766516..767025 - 510 WP_143023658.1 hypothetical protein -
ALW85_RS03690 (NE0707) 767048..767596 - 549 WP_143023659.1 type II secretion system protein M -
ALW85_RS03705 (NE0710) 768964..769368 - 405 WP_050731238.1 hypothetical protein -
ALW85_RS03710 (NE0711) 769783..770139 - 357 WP_011111330.1 YraN family protein -
ALW85_RS13915 770207..770461 - 255 WP_143023796.1 hypothetical protein -
ALW85_RS03720 (NE0712) 770567..770818 + 252 WP_041356508.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
ALW85_RS03725 (NE0713) 770815..771069 + 255 WP_011111332.1 Txe/YoeB family addiction module toxin Toxin
ALW85_RS03730 (NE0714) 771266..772168 + 903 WP_011111333.1 IS481 family transposase -
ALW85_RS13920 772252..773027 + 776 Protein_720 IS5 family transposase -
ALW85_RS03745 (NE0717) 773113..773727 - 615 WP_011111335.1 cold shock and DUF1294 domain-containing protein -
ALW85_RS03750 (NE0718) 773820..774359 - 540 WP_011111336.1 hypothetical protein -
ALW85_RS03755 (NE0719) 774690..775046 - 357 WP_011111337.1 YraN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 767637..773027 5390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10148.53 Da        Isoelectric Point: 9.6406

>T20957 WP_011111332.1 NC_004757:770815-771069 [Nitrosomonas europaea ATCC 19718]
VKLVFSEQAWEDYLYWQKTDRKTVQRIDTLVKEITRTPHEGTGKPEPLKHALSGYWSRRINNEHRIVYKIADDSLFIAQL
RYHY

Download         Length: 255 bp

>T20957 NC_004757:770815-771069 [Nitrosomonas europaea ATCC 19718]
GTGAAGCTGGTTTTCTCTGAGCAGGCCTGGGAAGACTATTTGTACTGGCAAAAGACAGACCGAAAAACCGTACAGCGAAT
CGATACGCTGGTGAAAGAGATTACAAGAACACCACACGAGGGTACCGGCAAACCCGAGCCACTGAAACATGCGCTGTCAG
GTTATTGGTCACGCCGTATCAATAACGAGCACCGGATCGTCTATAAAATTGCGGATGACTCGTTGTTTATTGCTCAACTG
AGATACCACTACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9245.50 Da        Isoelectric Point: 5.1051

>AT20957 WP_041356508.1 NC_004757:770567-770818 [Nitrosomonas europaea ATCC 19718]
MDAITYSTARAKLADTMNRVCDNHEPIIITRNGEQSVVMMSLDDFKALEETSYLLRSPKNAKRLLESIAALESGRGETRS
LAE

Download         Length: 252 bp

>AT20957 NC_004757:770567-770818 [Nitrosomonas europaea ATCC 19718]
ATGGACGCTATCACTTACAGCACTGCCAGAGCCAAACTTGCCGACACCATGAACCGCGTTTGCGATAACCATGAACCTAT
CATAATCACACGCAACGGAGAACAATCCGTTGTAATGATGTCGCTCGACGACTTCAAGGCGCTGGAGGAAACCTCTTACC
TGCTCCGTAGCCCAAAGAATGCGAAGCGGCTGCTGGAAAGCATCGCAGCTCTTGAATCAGGCAGAGGCGAAACGAGAAGC
CTGGCAGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q82WG5

Antitoxin

Source ID Structure
AlphaFold DB A0A837WYN7

References