Detailed information of TA system TA209569

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2139436..2139952
• Replicon: chromosome
• Accession: NZ_CP079634
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC19_AI1572C

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KW555_RS10430
• Protein ID: WP_040216106.1
• Coordinates: 2139436..2139720 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KW555_RS10435
• Protein ID: WP_064162488.1
• Coordinates: 2139710..2139952 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KW555_RS10405 (2134853)	2134853..2135116	-	264	WP_014908078.1	PTS sugar transporter subunit IIB	-
KW555_RS10410 (2135246)	2135246..2135419	+	174	WP_032425422.1	hypothetical protein	-
KW555_RS10415 (2135422)	2135422..2136165	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
KW555_RS10420 (2136522)	2136522..2138660	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
KW555_RS10425 (2138968)	2138968..2139432	+	465	WP_064162487.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
KW555_RS10430 (2139436)	2139436..2139720	-	285	WP_040216106.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KW555_RS10435 (2139710)	2139710..2139952	-	243	WP_064162488.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KW555_RS10440 (2140030)	2140030..2141940	-	1911	WP_023325426.1	PRD domain-containing protein	-
KW555_RS10445 (2141963)	2141963..2143117	-	1155	WP_064162489.1	lactonase family protein	-
KW555_RS10450 (2143184)	2143184..2143924	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11097.94 Da
• Isoelectric Point: 10.4962

>T209569 WP_040216106.1 NZ_CP079634:c2139720-2139436 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T209569 NZ_CP104136:465044-465490 [Sinorhizobium sp. C101]
GTGACTTTCCTGCTCGACGTCAATGTGCTGATTGCCTTAATCGATCCGGGCCATGTTGCCCATGACGATGCGCACGAATG
GTTCGCGGCGACGGGTCAGACCGCGTGGGCTACCTGCCCCATTACCGAAAACGGCGTCATCCGGATTGTCGGCAATCCCA
AATATCCGAATTCTCCCGGTTCACCGTCACTCGTGATGGAGATCGTCGGCAAAATGCGGTCGCTCCCCGGTCACAGTTTT
TGGCCGGACGATGTGAGCCTTGTCGGCTCAGGTGATATCGCTCCCACGAAAATCCTAACTTCGGGGCAGGTAACTGATAC
CTATCTCCTTGCGCTCGCCAAGGCGCGTGGGGGGCAACTGGCGACATTCGATCGCAAGCTCTCAGCAGCGGCGGTCACGA
GGGGTAATTCTGCCTTGCACCTGATCACTGCAACTCGGGTTCGTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9059.57 Da
• Isoelectric Point: 6.3340

>AT209569 WP_064162488.1 NZ_CP079634:c2139952-2139710 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT209569 NZ_CP104136:464820-465047 [Sinorhizobium sp. C101]
ATGAGAACGACCCTGGCAATCGACGACGATGTACTGATCGCCGCAAAGGCGATGGCAGCCCAGCAGCACCGGAGCGTCGG
CGAAGTCATTTCCGAACTGGCTAGACGTTCTTTGCGCAGACCGCGCAGCAGCGGCGAGCGCAATGGAATTCCTCTCTTAT
CACCTCAGCCGGATGCTCCGCCAGTGACGCTCGAGATCGTCAACGCCTTGCGTGACGAACTGCCGTGA