Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 2007925..2008735 Replicon chromosome
Accession NZ_CP079634
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC19_AI1572C

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag KW555_RS09855 Protein ID WP_004178461.1
Coordinates 2007925..2008458 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag KW555_RS09860 Protein ID WP_002887278.1
Coordinates 2008469..2008735 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW555_RS09850 (2006756) 2006756..2007877 + 1122 WP_004214138.1 cupin domain-containing protein -
KW555_RS09855 (2007925) 2007925..2008458 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
KW555_RS09860 (2008469) 2008469..2008735 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
KW555_RS09865 (2008838) 2008838..2010271 - 1434 WP_064162551.1 Cu(+)/Ag(+) sensor histidine kinase -
KW555_RS09870 (2010261) 2010261..2010944 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
KW555_RS09875 (2011116) 2011116..2012501 + 1386 WP_064162550.1 efflux transporter outer membrane subunit -
KW555_RS09880 (2012519) 2012519..2012863 + 345 WP_064162549.1 cation efflux system protein CusF -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(91-151)

Antitoxin

(2-86)


Sequences


Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T209568 WP_004178461.1 NZ_CP079634:c2008458-2007925 [Klebsiella pneumoniae subsp. pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T209568 NZ_CP104136:c139406-138999 [Sinorhizobium sp. C101]
ATGTATCTGGTTGACACCAACATCGTTTCGGAGGCGCGACGCGGCACGCCTCAGGCGCTGTCCTGGTTGCGTTCCGTCGA
TCCGCTCAGCATCCAACTGAGTGCACTGACCCTCGGCGAGATCATGCGCGGCATCGCACTGAAACAGAAGTCGGATCCGA
AGGCTGCCGCTCACCTCACCGAATGGCTGCGCAAGCTGCGCCACGACCATGGCGACCGCATCCTTCCGGTGACCGACCAG
ATCGCCGTCGAATGGGGCCGCATCGCCGCGATTCGGTCGCGTGGCGATATTGACGGGCTCCTCGCCGCGACCGCGATCGT
CCACGATCTGATCCTCGTCACGCGCAACGTCAGGGATTTTGAAGACACGGGCGCGTCAGTGATCAATCCTTGGGAGACAC
CGGCGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT209568 WP_002887278.1 NZ_CP079634:c2008735-2008469 [Klebsiella pneumoniae subsp. pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT209568 NZ_CP104136:c139660-139406 [Sinorhizobium sp. C101]
ATGGATTGGCAGCTGCAGGACGCGAAGAACCACTTCTCGAAAGTGGTGCAGAAGGCGCGCAACGAAGGGCCGCAGATCGT
CACGCTGCGTGGCGAGCGCACGGCCGTGGTGCTGTCCGCCCGCGACTATGACGCTCTGCGCGCCGGCCGGCCGACCCTGG
TCGACGATCTGCTTGGCGGTCCCCCTTGGGACGATGAGCTCGCCGAAGCCATCGAAGCGCGCGCCAAAACGCCGAGTCGC
GGCGTGGCCTTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A060VJ83


Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References