Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | kacAT/DUF1778(antitoxin) |
Location | 2007925..2008735 | Replicon | chromosome |
Accession | NZ_CP079634 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC19_AI1572C |
Toxin (Protein)
Gene name | KacT | Uniprot ID | A0A060VJ83 |
Locus tag | KW555_RS09855 | Protein ID | WP_004178461.1 |
Coordinates | 2007925..2008458 (-) | Length | 178 a.a. |
Antitoxin (Protein)
Gene name | KacA | Uniprot ID | J2E9Q7 |
Locus tag | KW555_RS09860 | Protein ID | WP_002887278.1 |
Coordinates | 2008469..2008735 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KW555_RS09850 (2006756) | 2006756..2007877 | + | 1122 | WP_004214138.1 | cupin domain-containing protein | - |
KW555_RS09855 (2007925) | 2007925..2008458 | - | 534 | WP_004178461.1 | type II toxin-antitoxin system toxin KacT | Toxin |
KW555_RS09860 (2008469) | 2008469..2008735 | - | 267 | WP_002887278.1 | type II toxin-antitoxin system antitoxin KacA | Antitoxin |
KW555_RS09865 (2008838) | 2008838..2010271 | - | 1434 | WP_064162551.1 | Cu(+)/Ag(+) sensor histidine kinase | - |
KW555_RS09870 (2010261) | 2010261..2010944 | - | 684 | WP_002887273.1 | copper response regulator transcription factor CusR | - |
KW555_RS09875 (2011116) | 2011116..2012501 | + | 1386 | WP_064162550.1 | efflux transporter outer membrane subunit | - |
KW555_RS09880 (2012519) | 2012519..2012863 | + | 345 | WP_064162549.1 | cation efflux system protein CusF | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 19810.65 Da Isoelectric Point: 5.2614
>T209568 WP_004178461.1 NZ_CP079634:c2008458-2007925 [Klebsiella pneumoniae subsp. pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES
Download Length: 534 bp
>T209568 NZ_CP104136:c139406-138999 [Sinorhizobium sp. C101]
ATGTATCTGGTTGACACCAACATCGTTTCGGAGGCGCGACGCGGCACGCCTCAGGCGCTGTCCTGGTTGCGTTCCGTCGA
TCCGCTCAGCATCCAACTGAGTGCACTGACCCTCGGCGAGATCATGCGCGGCATCGCACTGAAACAGAAGTCGGATCCGA
AGGCTGCCGCTCACCTCACCGAATGGCTGCGCAAGCTGCGCCACGACCATGGCGACCGCATCCTTCCGGTGACCGACCAG
ATCGCCGTCGAATGGGGCCGCATCGCCGCGATTCGGTCGCGTGGCGATATTGACGGGCTCCTCGCCGCGACCGCGATCGT
CCACGATCTGATCCTCGTCACGCGCAACGTCAGGGATTTTGAAGACACGGGCGCGTCAGTGATCAATCCTTGGGAGACAC
CGGCGTGA
ATGTATCTGGTTGACACCAACATCGTTTCGGAGGCGCGACGCGGCACGCCTCAGGCGCTGTCCTGGTTGCGTTCCGTCGA
TCCGCTCAGCATCCAACTGAGTGCACTGACCCTCGGCGAGATCATGCGCGGCATCGCACTGAAACAGAAGTCGGATCCGA
AGGCTGCCGCTCACCTCACCGAATGGCTGCGCAAGCTGCGCCACGACCATGGCGACCGCATCCTTCCGGTGACCGACCAG
ATCGCCGTCGAATGGGGCCGCATCGCCGCGATTCGGTCGCGTGGCGATATTGACGGGCTCCTCGCCGCGACCGCGATCGT
CCACGATCTGATCCTCGTCACGCGCAACGTCAGGGATTTTGAAGACACGGGCGCGTCAGTGATCAATCCTTGGGAGACAC
CGGCGTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9996.46 Da Isoelectric Point: 10.1757
>AT209568 WP_002887278.1 NZ_CP079634:c2008735-2008469 [Klebsiella pneumoniae subsp. pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR
Download Length: 267 bp
>AT209568 NZ_CP104136:c139660-139406 [Sinorhizobium sp. C101]
ATGGATTGGCAGCTGCAGGACGCGAAGAACCACTTCTCGAAAGTGGTGCAGAAGGCGCGCAACGAAGGGCCGCAGATCGT
CACGCTGCGTGGCGAGCGCACGGCCGTGGTGCTGTCCGCCCGCGACTATGACGCTCTGCGCGCCGGCCGGCCGACCCTGG
TCGACGATCTGCTTGGCGGTCCCCCTTGGGACGATGAGCTCGCCGAAGCCATCGAAGCGCGCGCCAAAACGCCGAGTCGC
GGCGTGGCCTTCTGA
ATGGATTGGCAGCTGCAGGACGCGAAGAACCACTTCTCGAAAGTGGTGCAGAAGGCGCGCAACGAAGGGCCGCAGATCGT
CACGCTGCGTGGCGAGCGCACGGCCGTGGTGCTGTCCGCCCGCGACTATGACGCTCTGCGCGCCGGCCGGCCGACCCTGG
TCGACGATCTGCTTGGCGGTCCCCCTTGGGACGATGAGCTCGCCGAAGCCATCGAAGCGCGCGCCAAAACGCCGAGTCGC
GGCGTGGCCTTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A060VJ83 |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 5ZGN | |
AlphaFold DB | A0A0H3GLZ1 |