Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1404224..1404843 Replicon chromosome
Accession NZ_CP079634
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC19_AI1572C

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KW555_RS06940 Protein ID WP_002892050.1
Coordinates 1404625..1404843 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KW555_RS06935 Protein ID WP_002892066.1
Coordinates 1404224..1404598 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW555_RS06925 (1399376) 1399376..1400569 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KW555_RS06930 (1400592) 1400592..1403738 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KW555_RS06935 (1404224) 1404224..1404598 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KW555_RS06940 (1404625) 1404625..1404843 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KW555_RS06945 (1405006) 1405006..1405572 + 567 WP_002892030.1 maltose O-acetyltransferase -
KW555_RS06950 (1405544) 1405544..1405684 - 141 WP_004147370.1 hypothetical protein -
KW555_RS06955 (1405705) 1405705..1406175 + 471 WP_002892026.1 YlaC family protein -
KW555_RS06960 (1406150) 1406150..1407601 - 1452 WP_064162152.1 PLP-dependent aminotransferase family protein -
KW555_RS06965 (1407702) 1407702..1408400 + 699 WP_004177238.1 GNAT family protein -
KW555_RS06970 (1408397) 1408397..1408537 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KW555_RS06975 (1408537) 1408537..1408800 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T209567 WP_002892050.1 NZ_CP079634:1404625-1404843 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T209567 NZ_CP104135:3093328-3093573 [Sinorhizobium sp. C101]
ATGAAGATCACGTACGACGAAACCAAGCGCCAGACCAACATCGGCAAGCACGCCTATGATTTCGCCGAGCTCGACATGGA
GTTCTTCTCTTCGTCCGTAGTGGTCCCGGCCAAGGAAGGCCGCTTCATGGCAATCGGCGTCCTGCGCAATGGCGTGATTG
CCGTGGTCTTCGCCCGCCTTGGCTCGGAAGGTATTTCGATTATCTCCATGCGTGACGCCAGCCGGAAGGAAAGGAGCTTA
CTATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT209567 WP_002892066.1 NZ_CP079634:1404224-1404598 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT209567 NZ_CP104135:3093570-3093893 [Sinorhizobium sp. C101]
ATGACGAACCCATCCCGCCGTATTCGCCATATCTCCGACAAGGAGGAGGCAGAAATTCAGCGCAAGATAGCCAGCGACCC
GGATGCTCCCGAGGCTACCGACGAGCAGCTTAGGCAAGCCAAGCCCTTCGCCGAGGCTTTTCCCGACCTCGCCGAGAGCA
TCAAGCGTGCCAGGGGCCGGCCAGCCATCGAGAAGCCCAGGCAGCAGCTATCCATCCGCTTGGATCCGGACATTATCGAG
CATTACAAGGCGACCGGCAAAGGCTGGCAGAGCCGAATGAATGACGACCTTAGAAAGGCCGCCGGGCTGAAGAAGGCCGG
CTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References