Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 32743..33386 | Replicon | plasmid pCMC307M_P3 |
| Accession | NZ_CP079632 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC18_CMC307MC | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | D8L2J9 |
| Locus tag | KW554_RS29270 | Protein ID | WP_001044770.1 |
| Coordinates | 32970..33386 (+) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | D5KTK7 |
| Locus tag | KW554_RS29265 | Protein ID | WP_001261282.1 |
| Coordinates | 32743..32973 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KW554_RS29230 (KW554_29215) | 28315..29181 | - | 867 | WP_004118283.1 | replication initiation protein | - |
| KW554_RS29235 (KW554_29220) | 29716..29820 | + | 105 | WP_032409716.1 | hypothetical protein | - |
| KW554_RS29240 (KW554_29225) | 29949..30206 | + | 258 | WP_000764642.1 | hypothetical protein | - |
| KW554_RS29245 (KW554_29230) | 30264..31040 | - | 777 | WP_000015958.1 | site-specific integrase | - |
| KW554_RS29250 (KW554_29235) | 31037..31780 | - | 744 | WP_000129823.1 | hypothetical protein | - |
| KW554_RS29255 (KW554_29240) | 31831..32181 | - | 351 | WP_000493378.1 | hypothetical protein | - |
| KW554_RS29260 (KW554_29245) | 32325..32786 | - | 462 | WP_072202616.1 | hypothetical protein | - |
| KW554_RS29265 (KW554_29250) | 32743..32973 | + | 231 | WP_001261282.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| KW554_RS29270 (KW554_29255) | 32970..33386 | + | 417 | WP_001044770.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| KW554_RS29275 (KW554_29260) | 33460..34149 | + | 690 | Protein_45 | AAA family ATPase | - |
| KW554_RS29280 (KW554_29265) | 34204..34901 | + | 698 | WP_223174630.1 | IS1 family transposase | - |
| KW554_RS29285 (KW554_29270) | 34986..35846 | - | 861 | WP_000027057.1 | broad-spectrum class A beta-lactamase TEM-1 | - |
| KW554_RS29290 (KW554_29275) | 36029..36346 | - | 318 | Protein_48 | recombinase family protein | - |
| KW554_RS29295 (KW554_29280) | 36546..37370 | - | 825 | WP_000722315.1 | oxacillin-hydrolyzing class D beta-lactamase OXA-9 | - |
| KW554_RS29300 (KW554_29285) | 37430..38218 | - | 789 | WP_001206315.1 | ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA1 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1A / blaOXA-9 / ant(3'')-Ia / aac(6')-Ib / blaCTX-M-15 / aac(3)-IId / blaSHV-187 / ARR-3 / ere(A) / cmlA1 / qacE / sul1 / blaOXA-181 | - | 1..77128 | 77128 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15106.52 Da Isoelectric Point: 7.1084
>T209565 WP_001044770.1 NZ_CP079632:32970-33386 [Klebsiella pneumoniae subsp. pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR
Download Length: 417 bp
>T209565 NZ_CP104135:c1458796-1458509 [Sinorhizobium sp. C101]
ATGCCCTATAGCCTCGAATTCCTGCCGTCTGCTCGAAAGGAATGGGACAAGTTAGGCGCGACGATCCGGCAGCAGTTTGT
AAAGAAGCTGCGTGAGCGTTTGGAGCGTCCCCGCATTCCGAGCGCCGCGCTAAGCGGAATGCCCGACCACTACAAAATCA
AACTGAGACAGCTTGGCTACCGTCTCGTCTACAGGGTCGATGATGGCACTGTCATTGTGTTGGTCGTGGCAGTCGGGAAG
CGAGAACGGGGGGACGTCTACAACACAATGCGAGCACGCGGGCGTTAG
ATGCCCTATAGCCTCGAATTCCTGCCGTCTGCTCGAAAGGAATGGGACAAGTTAGGCGCGACGATCCGGCAGCAGTTTGT
AAAGAAGCTGCGTGAGCGTTTGGAGCGTCCCCGCATTCCGAGCGCCGCGCTAAGCGGAATGCCCGACCACTACAAAATCA
AACTGAGACAGCTTGGCTACCGTCTCGTCTACAGGGTCGATGATGGCACTGTCATTGTGTTGGTCGTGGCAGTCGGGAAG
CGAGAACGGGGGGACGTCTACAACACAATGCGAGCACGCGGGCGTTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8756.83 Da Isoelectric Point: 4.4692
>AT209565 WP_001261282.1 NZ_CP079632:32743-32973 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL
Download Length: 231 bp
>AT209565 NZ_CP104135:c1459031-1458786 [Sinorhizobium sp. C101]
ATGCAGCGTGTAGAAGCCTCTGTAGCCGTGAGCGTTTCCGACTTGAAGAAGAGTCCCACGGCGGTAATGGGCGAGGCCCA
AGGCGAAGCGGTGGCCGTGCTGAACCACAATCGCGTCATGGCCTATCTGGTGCCTGCCGAGGTCTACGAATCCATGCTTG
AGCGGCTGGACGACCTCTATCTTGCCGAGCTCGTGAAAGAGCGAGCGGAGGAAAAGGGCGAGCCGGTCGATATCGATGCC
CTATAG
ATGCAGCGTGTAGAAGCCTCTGTAGCCGTGAGCGTTTCCGACTTGAAGAAGAGTCCCACGGCGGTAATGGGCGAGGCCCA
AGGCGAAGCGGTGGCCGTGCTGAACCACAATCGCGTCATGGCCTATCTGGTGCCTGCCGAGGTCTACGAATCCATGCTTG
AGCGGCTGGACGACCTCTATCTTGCCGAGCTCGTGAAAGAGCGAGCGGAGGAAAAGGGCGAGCCGGTCGATATCGATGCC
CTATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GYM2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GZG3 |