Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 5095717..5097398 | Replicon | chromosome |
| Accession | NZ_CP079629 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC18_CMC307MC | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | - |
| Locus tag | KW554_RS24930 | Protein ID | WP_004178299.1 |
| Coordinates | 5095717..5096634 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A6TH05 |
| Locus tag | KW554_RS24935 | Protein ID | WP_004177809.1 |
| Coordinates | 5096640..5097398 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KW554_RS24910 (5091023) | 5091023..5092543 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
| KW554_RS24915 (5092540) | 5092540..5093538 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| KW554_RS24920 (5093569) | 5093569..5094510 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| KW554_RS24925 (5094585) | 5094585..5095592 | + | 1008 | WP_004178300.1 | carbohydrate kinase family protein | - |
| KW554_RS24930 (5095717) | 5095717..5096634 | - | 918 | WP_004178299.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| KW554_RS24935 (5096640) | 5096640..5097398 | - | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| KW554_RS24940 (5097484) | 5097484..5098212 | - | 729 | WP_004178298.1 | response regulator transcription factor | - |
| KW554_RS24945 (5098485) | 5098485..5100632 | + | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
| KW554_RS24950 (5100862) | 5100862..5101548 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34649.06 Da Isoelectric Point: 5.4707
>T209561 WP_004178299.1 NZ_CP079629:c5096634-5095717 [Klebsiella pneumoniae subsp. pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
>T209561 NZ_CP104133:c1494205-1493759 [Sinorhizobium sp. K101]
GTGACTTTCCTGCTCGACGTCAATGTGCTGATTGCCTTAATCGATCCGGGCCATGTTGCCCATGACGATGCGCACGAATG
GTTCGCGGCGACGGGTCAGACCGCGTGGGCTACCTGCCCCATTACCGAAAACGGCGTCATCCGGATTGTCGGCAATCCCA
AATATCCGAATTCTCCCGGTTCACCGTCACTCGTGATGGAGATCGTCGGCAAAATGCGGTCGCTCCCCGGTCACAGTTTT
TGGCCGGACGATGTGAGCCTTGTCGGCTCAGGTGATATCGCTCCCACGAAAATCCTAACTTCGGGGCAGGTAACTGATAC
CTATCTCCTTGCGCTCGCCAAGGCGCGTGGGGGGCAACTGGCGACATTCGATCGCAAGCTCTCAGCAGCGGCGGTCACGA
GGGGTAATTCTGCCTTGCACCTGATCACTGCAACTCGGGTTCGTTAA
GTGACTTTCCTGCTCGACGTCAATGTGCTGATTGCCTTAATCGATCCGGGCCATGTTGCCCATGACGATGCGCACGAATG
GTTCGCGGCGACGGGTCAGACCGCGTGGGCTACCTGCCCCATTACCGAAAACGGCGTCATCCGGATTGTCGGCAATCCCA
AATATCCGAATTCTCCCGGTTCACCGTCACTCGTGATGGAGATCGTCGGCAAAATGCGGTCGCTCCCCGGTCACAGTTTT
TGGCCGGACGATGTGAGCCTTGTCGGCTCAGGTGATATCGCTCCCACGAAAATCCTAACTTCGGGGCAGGTAACTGATAC
CTATCTCCTTGCGCTCGCCAAGGCGCGTGGGGGGCAACTGGCGACATTCGATCGCAAGCTCTCAGCAGCGGCGGTCACGA
GGGGTAATTCTGCCTTGCACCTGATCACTGCAACTCGGGTTCGTTAA
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT209561 WP_004177809.1 NZ_CP079629:c5097398-5096640 [Klebsiella pneumoniae subsp. pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT209561 NZ_CP104133:c1494429-1494202 [Sinorhizobium sp. K101]
ATGAGAACGACCCTGGCAATCGACGACGATGTACTGATCGCCGCAAAGGCGATGGCAGCCCAGCAGCACCGGAGCGTCGG
CGAAGTCATTTCCGAACTGGCTAGACGTTCTTTGCGCAGACCGCGCAGCAGCGGCGAGCGCAATGGAATTCCTCTCTTAT
CACCTCAGCCGGATGCTCCGCCAGTGACGCTCGAGATCGTCAACGCCTTGCGTGACGAACTGCCGTGA
ATGAGAACGACCCTGGCAATCGACGACGATGTACTGATCGCCGCAAAGGCGATGGCAGCCCAGCAGCACCGGAGCGTCGG
CGAAGTCATTTCCGAACTGGCTAGACGTTCTTTGCGCAGACCGCGCAGCAGCGGCGAGCGCAATGGAATTCCTCTCTTAT
CACCTCAGCCGGATGCTCCGCCAGTGACGCTCGAGATCGTCAACGCCTTGCGTGACGAACTGCCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|