Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4938822..4939338 Replicon chromosome
Accession NZ_CP079629
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC18_CMC307MC

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag KW554_RS24130 Protein ID WP_004178374.1
Coordinates 4938822..4939106 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KW554_RS24135 Protein ID WP_002886901.1
Coordinates 4939096..4939338 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW554_RS24105 (4934306) 4934306..4934569 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
KW554_RS24110 (4934699) 4934699..4934872 + 174 WP_032408826.1 hypothetical protein -
KW554_RS24115 (4934875) 4934875..4935618 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KW554_RS24120 (4935975) 4935975..4938113 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KW554_RS24125 (4938354) 4938354..4938818 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KW554_RS24130 (4938822) 4938822..4939106 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KW554_RS24135 (4939096) 4939096..4939338 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KW554_RS24140 (4939416) 4939416..4941326 - 1911 WP_004178373.1 PRD domain-containing protein -
KW554_RS24145 (4941349) 4941349..4942503 - 1155 WP_004178372.1 lactonase family protein -
KW554_RS24150 (4942570) 4942570..4943310 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T209560 WP_004178374.1 NZ_CP079629:c4939106-4938822 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T209560 NZ_CP104133:c1395890-1395366 [Sinorhizobium sp. K101]
GTGCTTGACTGGCGGGAGGAACCTATCGGGCGCCACCATGACCGCAAGGCGTTCGATTGCGGCACGCCGGAACTGAACGA
GTATCTACGCCGGCACGCCCGTCAGAACCACGAAGGCGGCGGCTCCAAGACCTTCGTGGCGGTGGCTCCAACCGCGCCCG
AAACCATACTCGGCTACTATTCCATCAGCCCCGCTTCAATTGCCTTCGCAAAAGTCCCCGCCCCCCTGACCAAAGGATTG
GGCCGCTACGAGGTCGCCGTGTATCGGCTTGCCCGTCTGGCGGTGGCGCTTCCGCTGCAGGGTCGGGGGCTTGGCGGCGA
TCTTTTGCTGGCAGCCGGTGCGCGAGCGCTTGCCGTTGCCGCGCAGGTCGGCGGGGTGGCGCTTGCCATCGACGCCAAGG
ACGAGAAGGCGGCGTGCTGGTACGAGCGTTTCGGCGCAATGCCGCTGCTCGACAGCAGCCCCCTTAGCCTGATCCTGCCA
TTCAAGACCATCATCGACGCTCTGGATGCCGCGCAGGGCGAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT209560 WP_002886901.1 NZ_CP079629:c4939338-4939096 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT209560 NZ_CP104133:c1396173-1395883 [Sinorhizobium sp. K101]
ATGGCCCAGATGCAAGCTAATCGTGACGACCGCATCGAACTGCGCACCACGCGCGACGAAAAGCGGCTTCTCACCGCCGC
CGCCGCCCATGAGCGGCTGGACGTAACCAGCTTCATCATGCGCGCTGTCCTGCCGGCCGCGCGCGAGGTGGTTGAGAACG
CGGAACGTATTTCGCTGTCGGAGCGGGATTCCCTGCGCGTGCTCGATCTTCTGGAAAATCCGCCGGCCCCGACGCCGGCT
CTGCTCGCCGCAGCCCGCCGCCGTATCGCACGAGACGGCAAGAGTGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References