Detailed information of TA system TA020956

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-parD/RelE-RHH
• Location: 597544..598118
• Replicon: chromosome
• Accession: NC_004757
• Organism: Nitrosomonas europaea ATCC 19718

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ALW85_RS02915
• Protein ID: WP_041357045.1
• Coordinates: 597831..598118 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q82WV6
• Locus tag: ALW85_RS02910
• Protein ID: WP_011111181.1
• Coordinates: 597544..597831 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ALW85_RS02900 (NE0549)	593567..595915	+	2349	WP_011111179.1	TonB-dependent receptor	-
ALW85_RS02905 (NE0550)	595918..597150	+	1233	WP_011111180.1	PepSY domain-containing protein	-
ALW85_RS02910 (NE0551)	597544..597831	+	288	WP_011111181.1	hypothetical protein	Antitoxin
ALW85_RS02915 (NE0552)	597831..598118	+	288	WP_041357045.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
ALW85_RS02920 (NE0553)	598173..598589	-	417	WP_011111183.1	type II toxin-antitoxin system VapC family toxin	-
ALW85_RS02925 (NE0554)	598865..599368	+	504	WP_041356469.1	RNA polymerase sigma factor	-
ALW85_RS02930 (NE0555)	599368..600297	+	930	WP_011111185.1	FecR domain-containing protein	-
ALW85_RS02935 (NE0556)	600514..602859	+	2346	WP_011111186.1	TonB-dependent receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10888.32 Da
• Isoelectric Point: 5.0944

>T20956 WP_041357045.1 NC_004757:597831-598118 [Nitrosomonas europaea ATCC 19718]
MKLFWTPEALQDRDAIYDYIEVDNPRAALALDELFSEKAQRLPDHPALGHPGRVAGTRELIAHQNYIIIYDVTGELVRVL
RVLHAARQWPPSEND

Nucleotide

• Length: 288 bp

>T20956 NC_004757:597831-598118 [Nitrosomonas europaea ATCC 19718]
ATGAAATTGTTCTGGACACCAGAAGCGTTACAAGATCGCGATGCAATCTATGACTACATCGAAGTCGACAACCCGCGCGC
CGCTCTGGCGCTTGACGAGCTTTTTTCAGAGAAGGCGCAGCGTTTGCCTGATCATCCCGCCCTGGGTCATCCGGGCCGTG
TGGCTGGTACCCGTGAGCTAATTGCCCATCAGAATTACATCATCATTTATGATGTGACGGGCGAACTGGTGCGGGTGTTG
CGTGTGCTTCACGCGGCACGGCAATGGCCTCCTTCAGAAAACGATTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10858.07 Da
• Isoelectric Point: 5.9126

>AT20956 WP_011111181.1 NC_004757:597544-597831 [Nitrosomonas europaea ATCC 19718]
MSESTFTFRVDEDLKTEFSAAAKDCDRSGAQLLRDYMREFVKTRREVAEHDAWFRKQVQIGLDSANTGNLVPGDEVEAEF
AARRAATRRRLKASE

Nucleotide

• Length: 288 bp

>AT20956 NC_004757:597544-597831 [Nitrosomonas europaea ATCC 19718]
ATGTCAGAATCCACCTTTACTTTCCGGGTTGATGAAGACCTGAAAACCGAGTTCTCAGCGGCTGCCAAAGACTGCGACCG
TAGCGGTGCGCAACTGTTGCGCGACTACATGCGGGAGTTTGTAAAGACGCGGCGTGAAGTGGCCGAGCATGACGCATGGT
TCCGTAAACAGGTGCAAATTGGCCTGGACTCGGCTAATACTGGCAATCTGGTTCCGGGAGATGAGGTAGAGGCCGAGTTT
GCGGCCAGGCGGGCAGCCACACGTCGCAGGCTTAAAGCTTCAGAATGA

Structures

Antitoxin

• AlphaFold DB: Q82WV6