Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4222899..4223518 Replicon chromosome
Accession NZ_CP079629
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC18_CMC307MC

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KW554_RS20795 Protein ID WP_002892050.1
Coordinates 4223300..4223518 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KW554_RS20790 Protein ID WP_002892066.1
Coordinates 4222899..4223273 (+) Length 125 a.a.

Genomic Context


KW554_RS20780KW554_RS20785KW554_RS20790KW554_RS20795KW554_RS20800KW554_RS20810KW554_RS20820KW554_RS20805KW554_RS20815KW554_RS20825KW554_RS20830
Location: 4218051..4219244 (1194 bp)
Type: Others
Protein ID: WP_004177236.1
Location: 4219267..4222413 (3147 bp)
Type: Others
Protein ID: WP_218427596.1
Location: 4222899..4223273 (375 bp)
Type: Antitoxin
Protein ID: WP_002892066.1
Location: 4223300..4223518 (219 bp)
Type: Toxin
Protein ID: WP_002892050.1
Location: 4223677..4224243 (567 bp)
Type: Others
Protein ID: WP_002892030.1
Location: 4224376..4224846 (471 bp)
Type: Others
Protein ID: WP_002892026.1
Location: 4226373..4227071 (699 bp)
Type: Others
Protein ID: WP_004178762.1
Location: 4224215..4224355 (141 bp)
Type: Others
Protein ID: WP_004147370.1
Location: 4224821..4226272 (1452 bp)
Type: Others
Protein ID: WP_002892023.1
Location: 4227068..4227208 (141 bp)
Type: Others
Protein ID: WP_002892018.1
Location: 4227208..4227471 (264 bp)
Type: Others
Protein ID: WP_002892011.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KW554_RS20780 (4218051)4218051..4219244+1194WP_004177236.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-
KW554_RS20785 (4219267)4219267..4222413+3147WP_218427596.1multidrug efflux RND transporter permease subunit AcrB-
KW554_RS20790 (4222899)4222899..4223273+375WP_002892066.1Hha toxicity modulator TomBAntitoxin
KW554_RS20795 (4223300)4223300..4223518+219WP_002892050.1HHA domain-containing proteinToxin
KW554_RS20800 (4223677)4223677..4224243+567WP_002892030.1maltose O-acetyltransferase-
KW554_RS20805 (4224215)4224215..4224355-141WP_004147370.1hypothetical protein-
KW554_RS20810 (4224376)4224376..4224846+471WP_002892026.1YlaC family protein-
KW554_RS20815 (4224821)4224821..4226272-1452WP_002892023.1PLP-dependent aminotransferase family protein-
KW554_RS20820 (4226373)4226373..4227071+699WP_004178762.1GNAT family protein-
KW554_RS20825 (4227068)4227068..4227208-141WP_002892018.1type B 50S ribosomal protein L36-
KW554_RS20830 (4227208)4227208..4227471-264WP_002892011.1type B 50S ribosomal protein L31-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-116)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T209558 WP_002892050.1 NZ_CP079629:4223300-4223518 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T209558 NZ_CP104133:124122-124529 [Sinorhizobium sp. K101]
ATGTATCTGGTTGACACCAACATCGTTTCGGAGGCGCGACGCGGCACGCCTCAGGCGCTGTCCTGGTTGCGTTCCGTCGA
TCCGCTCAGCATCCAACTGAGTGCACTGACCCTCGGCGAGATCATGCGCGGCATCGCACTGAAACAGAAGTCGGATCCGA
AGGCTGCCGCTCACCTCACCGAATGGCTGCGCAAGCTGCGCCACGACCATGGCGACCGCATCCTTCCGGTGACCGACCAG
ATCGCCGTCGAATGGGGCCGCATCGCCGCGATTCGGTCGCGTGGCGATATTGACGGGCTCCTCGCCGCGACCGCGATCGT
CCACGATCTGATCCTCGTCACGCGCAACGTCAGGGATTTTGAAGACACGGGCGCGTCAGTGATCAATCCTTGGGAGACAC
CGGCGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT209558 WP_002892066.1 NZ_CP079629:4222899-4223273 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT209558 NZ_CP104133:123868-124122 [Sinorhizobium sp. K101]
ATGGATTGGCAGCTGCAGGACGCGAAGAACCACTTCTCGAAAGTGGTGCAGAAGGCGCGCAACGAAGGGCCGCAGATCGT
CACGCTGCGTGGCGAGCGCACGGCCGTGGTGCTGTCCGCCCGCGACTATGACGCTCTGCGCGCCGGCCGGCCGACCCTGG
TCGACGATCTGCTTGGCGGTCCCCCTTGGGACGATGAGCTCGCCGAAGCCATCGAAGCGCGCGCCAAAACGCCGAGTCGC
GGCGTGGCCTTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A2P8K6F2


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GJ93

References