Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 4222899..4223518 | Replicon | chromosome |
Accession | NZ_CP079629 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC18_CMC307MC |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | KW554_RS20795 | Protein ID | WP_002892050.1 |
Coordinates | 4223300..4223518 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | KW554_RS20790 | Protein ID | WP_002892066.1 |
Coordinates | 4222899..4223273 (+) | Length | 125 a.a. |
Genomic Context
Location: 4218051..4219244 (1194 bp)
Type: Others
Protein ID: WP_004177236.1
Type: Others
Protein ID: WP_004177236.1
Location: 4219267..4222413 (3147 bp)
Type: Others
Protein ID: WP_218427596.1
Type: Others
Protein ID: WP_218427596.1
Location: 4222899..4223273 (375 bp)
Type: Antitoxin
Protein ID: WP_002892066.1
Type: Antitoxin
Protein ID: WP_002892066.1
Location: 4223300..4223518 (219 bp)
Type: Toxin
Protein ID: WP_002892050.1
Type: Toxin
Protein ID: WP_002892050.1
Location: 4223677..4224243 (567 bp)
Type: Others
Protein ID: WP_002892030.1
Type: Others
Protein ID: WP_002892030.1
Location: 4224376..4224846 (471 bp)
Type: Others
Protein ID: WP_002892026.1
Type: Others
Protein ID: WP_002892026.1
Location: 4226373..4227071 (699 bp)
Type: Others
Protein ID: WP_004178762.1
Type: Others
Protein ID: WP_004178762.1
Location: 4224215..4224355 (141 bp)
Type: Others
Protein ID: WP_004147370.1
Type: Others
Protein ID: WP_004147370.1
Location: 4224821..4226272 (1452 bp)
Type: Others
Protein ID: WP_002892023.1
Type: Others
Protein ID: WP_002892023.1
Location: 4227068..4227208 (141 bp)
Type: Others
Protein ID: WP_002892018.1
Type: Others
Protein ID: WP_002892018.1
Location: 4227208..4227471 (264 bp)
Type: Others
Protein ID: WP_002892011.1
Type: Others
Protein ID: WP_002892011.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KW554_RS20780 (4218051) | 4218051..4219244 | + | 1194 | WP_004177236.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
KW554_RS20785 (4219267) | 4219267..4222413 | + | 3147 | WP_218427596.1 | multidrug efflux RND transporter permease subunit AcrB | - |
KW554_RS20790 (4222899) | 4222899..4223273 | + | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
KW554_RS20795 (4223300) | 4223300..4223518 | + | 219 | WP_002892050.1 | HHA domain-containing protein | Toxin |
KW554_RS20800 (4223677) | 4223677..4224243 | + | 567 | WP_002892030.1 | maltose O-acetyltransferase | - |
KW554_RS20805 (4224215) | 4224215..4224355 | - | 141 | WP_004147370.1 | hypothetical protein | - |
KW554_RS20810 (4224376) | 4224376..4224846 | + | 471 | WP_002892026.1 | YlaC family protein | - |
KW554_RS20815 (4224821) | 4224821..4226272 | - | 1452 | WP_002892023.1 | PLP-dependent aminotransferase family protein | - |
KW554_RS20820 (4226373) | 4226373..4227071 | + | 699 | WP_004178762.1 | GNAT family protein | - |
KW554_RS20825 (4227068) | 4227068..4227208 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
KW554_RS20830 (4227208) | 4227208..4227471 | - | 264 | WP_002892011.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T209558 WP_002892050.1 NZ_CP079629:4223300-4223518 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T209558 NZ_CP104133:124122-124529 [Sinorhizobium sp. K101]
ATGTATCTGGTTGACACCAACATCGTTTCGGAGGCGCGACGCGGCACGCCTCAGGCGCTGTCCTGGTTGCGTTCCGTCGA
TCCGCTCAGCATCCAACTGAGTGCACTGACCCTCGGCGAGATCATGCGCGGCATCGCACTGAAACAGAAGTCGGATCCGA
AGGCTGCCGCTCACCTCACCGAATGGCTGCGCAAGCTGCGCCACGACCATGGCGACCGCATCCTTCCGGTGACCGACCAG
ATCGCCGTCGAATGGGGCCGCATCGCCGCGATTCGGTCGCGTGGCGATATTGACGGGCTCCTCGCCGCGACCGCGATCGT
CCACGATCTGATCCTCGTCACGCGCAACGTCAGGGATTTTGAAGACACGGGCGCGTCAGTGATCAATCCTTGGGAGACAC
CGGCGTGA
ATGTATCTGGTTGACACCAACATCGTTTCGGAGGCGCGACGCGGCACGCCTCAGGCGCTGTCCTGGTTGCGTTCCGTCGA
TCCGCTCAGCATCCAACTGAGTGCACTGACCCTCGGCGAGATCATGCGCGGCATCGCACTGAAACAGAAGTCGGATCCGA
AGGCTGCCGCTCACCTCACCGAATGGCTGCGCAAGCTGCGCCACGACCATGGCGACCGCATCCTTCCGGTGACCGACCAG
ATCGCCGTCGAATGGGGCCGCATCGCCGCGATTCGGTCGCGTGGCGATATTGACGGGCTCCTCGCCGCGACCGCGATCGT
CCACGATCTGATCCTCGTCACGCGCAACGTCAGGGATTTTGAAGACACGGGCGCGTCAGTGATCAATCCTTGGGAGACAC
CGGCGTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT209558 WP_002892066.1 NZ_CP079629:4222899-4223273 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT209558 NZ_CP104133:123868-124122 [Sinorhizobium sp. K101]
ATGGATTGGCAGCTGCAGGACGCGAAGAACCACTTCTCGAAAGTGGTGCAGAAGGCGCGCAACGAAGGGCCGCAGATCGT
CACGCTGCGTGGCGAGCGCACGGCCGTGGTGCTGTCCGCCCGCGACTATGACGCTCTGCGCGCCGGCCGGCCGACCCTGG
TCGACGATCTGCTTGGCGGTCCCCCTTGGGACGATGAGCTCGCCGAAGCCATCGAAGCGCGCGCCAAAACGCCGAGTCGC
GGCGTGGCCTTCTGA
ATGGATTGGCAGCTGCAGGACGCGAAGAACCACTTCTCGAAAGTGGTGCAGAAGGCGCGCAACGAAGGGCCGCAGATCGT
CACGCTGCGTGGCGAGCGCACGGCCGTGGTGCTGTCCGCCCGCGACTATGACGCTCTGCGCGCCGGCCGGCCGACCCTGG
TCGACGATCTGCTTGGCGGTCCCCCTTGGGACGATGAGCTCGCCGAAGCCATCGAAGCGCGCGCCAAAACGCCGAGTCGC
GGCGTGGCCTTCTGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |