Detailed information of TA system TA209556

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2894109..2895697
• Replicon: chromosome
• Accession: NZ_CP079629
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC18_CMC307MC

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KW554_RS14490
• Protein ID: WP_004179815.1
• Coordinates: 2894109..2895431 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KW554_RS14495
• Protein ID: WP_004176198.1
• Coordinates: 2895431..2895697 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KW554_RS14475 (2889165)	2889165..2891666	+	2502	WP_004179823.1	fimbria/pilus outer membrane usher protein	-
KW554_RS14480 (2891654)	2891654..2892658	+	1005	WP_004179822.1	fimbrial protein	-
KW554_RS14485 (2892800)	2892800..2894092	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
KW554_RS14490 (2894109)	2894109..2895431	-	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
KW554_RS14495 (2895431)	2895431..2895697	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KW554_RS14500 (2895963)	2895963..2896289	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
KW554_RS14505 (2896286)	2896286..2896786	-	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
KW554_RS14510 (2896764)	2896764..2898143	-	1380	WP_004179808.1	nucleobase:cation symporter-2 family protein	-
KW554_RS14515 (2898488)	2898488..2899642	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
KW554_RS14520 (2899623)	2899623..2900546	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T209556 WP_004179815.1 NZ_CP079629:c2895431-2894109 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T209556 NZ_CP104132:240335-240718 [Sinorhizobium sp. K101]
GTGATTCTTGCCGACACTTCAATCTGGATTGATCATTTCCGGCATACCGATGCCGAGCTGCGTAGGATTGTTGAGGACGA
TCGTCTCCTCTGCCATCCGGCCGTGATCGGAGAGCTTGCACTCGGCAGTCTTCGGGAACGCAGTAGCGTGATAGCATTCC
TGATGGCTCAGCGCGAAGCACTCGTCGCAACGCACCACGAGGTCATGATGATGGTTGATCGCCACGCCATTTTCAGCATG
GGGATCGGCTACACGGATGCCCATTTGCTGGCCTCGGTTCTTCTCGATAAGCGAGTGGCTTTGTGGACGAGAGACAAGCG
TTTGCGGGCAGCGGCCGAAAAGGCGGGGGCGTCGCTGCACACCCCCGCCCATACACGGAACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT209556 WP_004176198.1 NZ_CP079629:c2895697-2895431 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT209556 NZ_CP104132:240138-240338 [Sinorhizobium sp. K101]
ATGCGATCGACTATCAACCTCGACGACGCTCTCATGGAAACGGCCAAGTCCCTAACCGGCACGAAAGAAACCGCCGCTCT
GGTCCGCCAGGCATTGGAGACGCTTGTCCGTGTGGAGTCAGGAAAACGCCTCATCGCGCTCGGGGGAACTATGCCGGATG
CGGAGGCAGCTCCACGCCGCCGGAGCGCAGCTGCCAAGTGA