Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 536241..536887 Replicon chromosome
Accession NC_004757
Organism Nitrosomonas europaea ATCC 19718

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ALW85_RS02635 Protein ID WP_011111129.1
Coordinates 536477..536887 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A837WTB6
Locus tag ALW85_RS02630 Protein ID WP_041356451.1
Coordinates 536241..536480 (+) Length 80 a.a.

Genomic Context

ALW85_RS02620ALW85_RS02630ALW85_RS02635ALW85_RS02640ALW85_RS02645ALW85_RS02650ALW85_RS02655ALW85_RS13885ALW85_RS02580ALW85_RS02585ALW85_RS02590ALW85_RS02595ALW85_RS02600ALW85_RS02660
Location: 535662..535853 (192 bp)
Type: Others
Protein ID: WP_011111127.1
Location: 536241..536480 (240 bp)
Type: Antitoxin
Protein ID: WP_041356451.1
Location: 536477..536887 (411 bp)
Type: Toxin
Protein ID: WP_011111129.1
Location: 536923..537672 (750 bp)
Type: Others
Protein ID: WP_011111130.1
Location: 537687..538634 (948 bp)
Type: Others
Protein ID: WP_011111131.1
Location: 538693..539253 (561 bp)
Type: Others
Protein ID: WP_041357027.1
Location: 539262..541229 (1968 bp)
Type: Others
Protein ID: WP_011111133.1
Location: 531738..531872 (135 bp)
Type: Others
Protein ID: Protein_496
Location: 531968..532285 (318 bp)
Type: Others
Protein ID: WP_011111121.1
Location: 532298..532621 (324 bp)
Type: Others
Protein ID: WP_011111122.1
Location: 532909..533976 (1068 bp)
Type: Others
Protein ID: WP_011111123.1
Location: 533980..534294 (315 bp)
Type: Others
Protein ID: WP_041356444.1
Location: 534294..534614 (321 bp)
Type: Others
Protein ID: WP_011111125.1
Location: 541277..541774 (498 bp)
Type: Others
Protein ID: WP_011111134.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ALW85_RS13885531738..531872-135Protein_496IS3 family transposase-
ALW85_RS02580 (NE0490)531968..532285-318WP_011111121.1HigA family addiction module antidote protein-
ALW85_RS02585 (NE0491)532298..532621-324WP_011111122.1type II toxin-antitoxin system RelE/ParE family toxin-
ALW85_RS02590 (NE0492)532909..533976-1068WP_011111123.1Rpn family recombination-promoting nuclease/putative transposase-
ALW85_RS02595 (NE0493)533980..534294-315WP_041356444.1helix-turn-helix domain-containing protein-
ALW85_RS02600 (NE0494)534294..534614-321WP_011111125.1type II toxin-antitoxin system RelE/ParE family toxin-
ALW85_RS02620 (NE0496)535662..535853+192WP_011111127.1hypothetical protein-
ALW85_RS02630 (NE0497)536241..536480+240WP_041356451.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
ALW85_RS02635 (NE0498)536477..536887+411WP_011111129.1type II toxin-antitoxin system VapC family toxinToxin
ALW85_RS02640 (NE0499)536923..537672+750WP_011111130.1glycosyltransferase-
ALW85_RS02645 (NE0500)537687..538634+948WP_011111131.1SDR family oxidoreductase-
ALW85_RS02650 (NE0501)538693..539253+561WP_041357027.1sugar transferase-
ALW85_RS02655 (NE0502)539262..541229+1968WP_011111133.1polysaccharide biosynthesis protein-
ALW85_RS02660 (NE0503)541277..541774-498WP_011111134.1DUF4124 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-127)

Antitoxin

SpoVT-AbrB domain

(10-52)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15118.58 Da        Isoelectric Point: 5.1846

>T20955 WP_011111129.1 NC_004757:536477-536887 [Nitrosomonas europaea ATCC 19718]
MISPRYLLDTNILSDLVRYPQGVIARRIEEVGEAAVCTSIIVAAELRFGAARRNSLRLTRQVEAILAAIEVLPLDTPVDR
AYAQLRWVLEQSGQVIGPNDMLITAQAMASQCVLITANLDKFSRVGELQVENWLVR

Download         Length: 411 bp

>T20955 NC_004757:536477-536887 [Nitrosomonas europaea ATCC 19718]
ATGATTTCACCGCGTTATTTACTGGATACGAATATTCTTTCTGATCTGGTTCGCTATCCACAAGGAGTTATAGCCCGACG
AATTGAGGAAGTTGGTGAAGCAGCGGTATGTACGTCGATTATCGTTGCCGCAGAATTGAGGTTTGGGGCTGCCAGGAGAA
ATTCCTTAAGGCTGACCAGGCAGGTGGAAGCCATTCTGGCGGCAATCGAGGTGTTGCCGCTTGATACGCCAGTGGACCGC
GCTTATGCGCAATTGCGCTGGGTGCTTGAGCAATCTGGACAAGTCATCGGGCCTAACGATATGCTGATTACGGCCCAGGC
TATGGCAAGTCAATGTGTGCTGATTACTGCCAATCTGGATAAATTTTCCCGGGTTGGGGAATTGCAGGTAGAAAACTGGT
TAGTGAGGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9127.58 Da        Isoelectric Point: 4.6151

>AT20955 WP_041356451.1 NC_004757:536241-536480 [Nitrosomonas europaea ATCC 19718]
MLSERYVRLFRNGKNQAVRIPREFELNAQEVIMRREGNRLIIEPVPPKGLLVVLAELAPLEENFSDIDTRLAPLDDIDL

Download         Length: 240 bp

>AT20955 NC_004757:536241-536480 [Nitrosomonas europaea ATCC 19718]
ATGTTATCTGAACGTTATGTCAGATTGTTTCGTAACGGCAAGAATCAGGCTGTGCGTATTCCTCGCGAATTCGAGCTGAA
TGCGCAGGAGGTAATCATGCGCCGGGAAGGTAATCGTTTGATTATTGAACCGGTACCCCCAAAAGGCTTGCTGGTAGTGT
TGGCAGAGTTGGCACCACTTGAGGAAAATTTTTCTGATATTGATACCAGATTGGCACCGTTGGATGACATTGATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A837WTB6

References