Detailed information of TA system TA209547

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 849105..849762
• Replicon: chromosome
• Accession: NZ_CP079629
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC18_CMC307MC

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KW554_RS04235
• Protein ID: WP_004181233.1
• Coordinates: 849352..849762 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: KW554_RS04230
• Protein ID: WP_002916312.1
• Coordinates: 849105..849371 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KW554_RS04205 (844261)	844261..845694	-	1434	WP_004181234.1	6-phospho-beta-glucosidase	-
KW554_RS04210 (845813)	845813..846541	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
KW554_RS04215 (846591)	846591..846902	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
KW554_RS04220 (847066)	847066..847725	+	660	WP_002916317.1	hemolysin III family protein	-
KW554_RS04225 (847876)	847876..848859	-	984	WP_002916313.1	tRNA-modifying protein YgfZ	-
KW554_RS04230 (849105)	849105..849371	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
KW554_RS04235 (849352)	849352..849762	+	411	WP_004181233.1	protein YgfX	Toxin
KW554_RS04240 (849769)	849769..850290	-	522	WP_004144730.1	flavodoxin FldB	-
KW554_RS04245 (850391)	850391..851287	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
KW554_RS04250 (851310)	851310..852023	+	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
KW554_RS04255 (852029)	852029..853762	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16121.92 Da
• Isoelectric Point: 11.1565

>T209547 WP_004181233.1 NZ_CP079629:849352-849762 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T209547 NZ_CP104129:562718-563125 [Sinorhizobium sp. M103]
ATGTATCTGGTTGACACCAACATCGTTTCGGAGGCGCGACGCGGCACGCCTCAGGCGCTGTCCTGGTTGCGTTCCGTCGA
TCCGCTCAGCATCCAACTGAGTGCACTGACCCTCGGCGAGATCATGCGCGGCATCGCACTGAAACAGAAGTCGGATCCGA
AGGCTGCCGCTCACCTCACCGAATGGCTGCGCAAGCTGCGCCACGACCATGGCGACCGCATCCTTCCGGTGACCGACCAG
ATCGCCGTCGAATGGGGCCGCATCGCCGCGATTCGGTCGCGTGGCGATATTGACGGGCTCCTCGCCGCGACCGCGATCGT
CCACGATCTGATCCTCGTCACGCGCAACGTCAGGGATTTTGAAGACACGGGCGCGTCAGTGATCAATCCTTGGGAGACAC
CGGCGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT209547 WP_002916312.1 NZ_CP079629:849105-849371 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT209547 NZ_CP104129:562464-562718 [Sinorhizobium sp. M103]
ATGGATTGGCAGCTGCAGGACGCGAAGAACCACTTCTCGAAAGTGGTGCAGAAGGCGCGCAACGAAGGGCCGCAGATCGT
CACGCTGCGTGGCGAGCGCACGGCCGTGGTGCTGTCCGCCCGCGACTATGACGCTCTGCGCGCCGGCCGGCCGACCCTGG
TCGACGATCTGCTTGGCGGTCCCCCTTGGGACGATGAGCTCGCCGAAGCCATCGAAGCGCGCGCCAAAACGCCGAGTCGC
GGCGTGGCCTTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41