Detailed information of TA system TA209541

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5110433..5112114
• Replicon: chromosome
• Accession: NZ_CP079624
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC17_CMC307PC

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: KW552_RS24985
• Protein ID: WP_004178299.1
• Coordinates: 5110433..5111350 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: KW552_RS24990
• Protein ID: WP_004177809.1
• Coordinates: 5111356..5112114 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KW552_RS24965 (5105739)	5105739..5107259	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
KW552_RS24970 (5107256)	5107256..5108254	+	999	WP_002885172.1	ribose ABC transporter permease	-
KW552_RS24975 (5108285)	5108285..5109226	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
KW552_RS24980 (5109301)	5109301..5110308	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
KW552_RS24985 (5110433)	5110433..5111350	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KW552_RS24990 (5111356)	5111356..5112114	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KW552_RS24995 (5112200)	5112200..5112928	-	729	WP_004178298.1	response regulator transcription factor	-
KW552_RS25000 (5113201)	5113201..5115348	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
KW552_RS25005 (5115578)	5115578..5116264	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T209541 WP_004178299.1 NZ_CP079624:c5111350-5110433 [Klebsiella pneumoniae subsp. pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T209541 NZ_CP104127:3093304-3093549 [Sinorhizobium sp. M103]
ATGAAGATCACGTACGACGAAACCAAGCGCCAGACCAACATCGGCAAGCACGCCTATGATTTCGCCGAGCTCGACATGGA
GTTCTTCTCTTCGTCCGTAGTGGTCCCGGCCAAGGAAGGCCGCTTCATGGCAATCGGCGTCCTGCGCAATGGCGTGATTG
CCGTGGTCTTCGCCCGCCTTGGCTCGGAAGGTATTTCGATTATCTCCATGCGTGACGCCAGCCGGAAGGAAAGGAGCTTA
CTATGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT209541 WP_004177809.1 NZ_CP079624:c5112114-5111356 [Klebsiella pneumoniae subsp. pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT209541 NZ_CP104127:3093546-3093869 [Sinorhizobium sp. M103]
ATGACGAACCCATCCCGCCGTATTCGCCATATCTCCGACAAGGAGGAGGCAGAAATTCAGCGCAAGATAGCCAGCGACCC
GGATGCTCCCGAGGCTACCGACGAGCAGCTTAGGCAAGCCAAGCCCTTCGCCGAGGCTTTTCCCGACCTCGCCGAGAGCA
TCAAGCGTGCCAGGGGCCGGCCAGCCATCGAGAAGCCCAGGCAGCAGCTATCCATCCGCTTGGATCCGGACATTATCGAG
CATTACAAGGCGACCGGCAAAGGCTGGCAGAGCCGAATGAATGACGACCTTAGAAAGGCCGCCGGGCTGAAGAAGGCCGG
CTAG

Structures

Antitoxin

• AlphaFold DB: A6TH05