Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4953538..4954054 Replicon chromosome
Accession NZ_CP079624
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC17_CMC307PC

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag KW552_RS24185 Protein ID WP_004178374.1
Coordinates 4953538..4953822 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KW552_RS24190 Protein ID WP_002886901.1
Coordinates 4953812..4954054 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW552_RS24160 (4949022) 4949022..4949285 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
KW552_RS24165 (4949415) 4949415..4949588 + 174 WP_032408826.1 hypothetical protein -
KW552_RS24170 (4949591) 4949591..4950334 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KW552_RS24175 (4950691) 4950691..4952829 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KW552_RS24180 (4953070) 4953070..4953534 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KW552_RS24185 (4953538) 4953538..4953822 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KW552_RS24190 (4953812) 4953812..4954054 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KW552_RS24195 (4954132) 4954132..4956042 - 1911 WP_004178373.1 PRD domain-containing protein -
KW552_RS24200 (4956065) 4956065..4957219 - 1155 WP_004178372.1 lactonase family protein -
KW552_RS24205 (4957286) 4957286..4958026 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T209540 WP_004178374.1 NZ_CP079624:c4953822-4953538 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T209540 NZ_CP104127:c2652612-2652316 [Sinorhizobium sp. M103]
ATGATCGTTGGTTTTCGGGATGATTGGTTGCGGGCTTTTTTCGTGGACGATGCCCATTCTCGCAACATCCCGTCGGACCT
TGAGGTCCGGTTGTTCCGCAAACTCCAGATGATCGATGATGCCACGACAGATCAGGACTTACGTGTGCCGCCCAGCAACT
TCTTCGAGAAACTGCGCGGCAATCTGGCGGGTTTCCATTCGATCCGTGTGAACCAGCAATGGCGGCTGATCTTCCGCTGG
GATGGCGAACGCGGCGAGGCGGACGGGATTTACCTGGACGATCACAGCTACCGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT209540 WP_002886901.1 NZ_CP079624:c4954054-4953812 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT209540 NZ_CP104127:c2652302-2651994 [Sinorhizobium sp. M103]
ATGCTGACGACCAAGCGCAAGCCGGCGACTGTCGGCGAGATTTTGACCGAGGAATTCATGGAGCCGATGGGTCTGACGCA
GGGCGCATTAGCCGAGGCGATGGGCGTGCAACGCAAGCACGTCAACGAGTTGTGCGGGAACCGCAGGAACGTGACCGCCG
CAACCGCACTCATCCTTGCCCGCGTTTTTGGCAACAGCCCGGACTTCTGGCTCAACGTGCAGCGTCGCAACGATCTTTGG
GAGGTAATGAACACGCCCAAGGAACGCGAGCGTGTCGAGCGAGCGCGACCGTTGAAGCACGCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References