Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4237615..4238234 Replicon chromosome
Accession NZ_CP079624
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC17_CMC307PC

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KW552_RS20850 Protein ID WP_002892050.1
Coordinates 4238016..4238234 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KW552_RS20845 Protein ID WP_002892066.1
Coordinates 4237615..4237989 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW552_RS20835 (4232767) 4232767..4233960 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KW552_RS20840 (4233983) 4233983..4237129 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KW552_RS20845 (4237615) 4237615..4237989 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KW552_RS20850 (4238016) 4238016..4238234 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KW552_RS20855 (4238393) 4238393..4238959 + 567 WP_002892030.1 maltose O-acetyltransferase -
KW552_RS20860 (4238931) 4238931..4239071 - 141 WP_004147370.1 hypothetical protein -
KW552_RS20865 (4239092) 4239092..4239562 + 471 WP_002892026.1 YlaC family protein -
KW552_RS20870 (4239537) 4239537..4240988 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KW552_RS20875 (4241089) 4241089..4241787 + 699 WP_004178762.1 GNAT family protein -
KW552_RS20880 (4241784) 4241784..4241924 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KW552_RS20885 (4241924) 4241924..4242187 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T209538 WP_002892050.1 NZ_CP079624:4238016-4238234 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T209538 NZ_CP104127:c1012506-1012252 [Sinorhizobium sp. M103]
ATGAAAAAGCGTCGCAGAGCCACGCTGGAACTGATCTTCGCCCGCCCGGTCAACGGCTCGATCCGCTGGGTCGACATAGA
GGCGCTGTTTGTAGCCCTCGGGGCGGAGGTCAGCGAGCGGCAAGGTTCGCGGACAGGCGTGTTCCTGTTCGGCGAAGTGC
GCGTCTTTCATCGCCCGCATCCTTCACCGGATACGGATAAAGGTGCGGTTGCCAGCATCCGTAAATGGCTGGACGAACAC
GGAGTAAAGCCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT209538 WP_002892066.1 NZ_CP079624:4237615-4237989 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT209538 NZ_CP104127:c1012255-1011923 [Sinorhizobium sp. M103]
ATGAACAATGTCGTTGAAATCAATGGCGAGAAGGCGGTCATCGCTTTCGATCCCGAGATTAAGATGCTGCGCGGCGAGTT
TGTCGCCCTGAATGGCGGGGCCGACTTCTATGCCGAGAGCGTCCACGATCTGATTGAGGAAGGCCGCAAGTCGCTGGCCG
TCTATCTCGAAATGTGCCGGGAAAAGGGTATTGAGCCTCGCCGGAAGTTCTCTGGCAAGTTCAATGTCCGCCTCACCCCT
GACGAACATGCCGCAGCAGTCATTGCTGCCGCAGCCGCGGGCAAGAGCCTGAATGAATGGATCGTCGGGACCATCAGGGA
GGCCGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References