Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 519527..520161 Replicon chromosome
Accession NC_004757
Organism Nitrosomonas europaea ATCC 19718

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ALW85_RS02530 Protein ID WP_011111110.1
Coordinates 519760..520161 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q82X22
Locus tag ALW85_RS02525 Protein ID WP_011111109.1
Coordinates 519527..519760 (+) Length 78 a.a.

Genomic Context

ALW85_RS02500ALW85_RS02505ALW85_RS02510ALW85_RS02515ALW85_RS13875ALW85_RS02525ALW85_RS02530ALW85_RS02535ALW85_RS02550ALW85_RS02520ALW85_RS02540ALW85_RS02545
Location: 514553..514918 (366 bp)
Type: Others
Protein ID: WP_011111104.1
Location: 515103..516257 (1155 bp)
Type: Others
Protein ID: WP_011111105.1
Location: 516404..516625 (222 bp)
Type: Others
Protein ID: WP_011111106.1
Location: 516603..516857 (255 bp)
Type: Others
Protein ID: WP_011111107.1
Location: 517180..517371 (192 bp)
Type: Others
Protein ID: WP_143023752.1
Location: 519527..519760 (234 bp)
Type: Antitoxin
Protein ID: WP_011111109.1
Location: 519760..520161 (402 bp)
Type: Toxin
Protein ID: WP_011111110.1
Location: 520320..520748 (429 bp)
Type: Others
Protein ID: WP_011111111.1
Location: 521508..522863 (1356 bp)
Type: Others
Protein ID: WP_011111114.1
Location: 517316..519226 (1911 bp)
Type: Others
Protein ID: WP_011111108.1
Location: 520813..521118 (306 bp)
Type: Others
Protein ID: WP_011111112.1
Location: 521128..521406 (279 bp)
Type: Others
Protein ID: WP_041357019.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ALW85_RS02500 (NE0473)514553..514918+366WP_011111104.1hypothetical protein-
ALW85_RS02505 (NE0474)515103..516257+1155WP_011111105.1ATP-binding protein-
ALW85_RS02510 (NE0475)516404..516625+222WP_011111106.1ribbon-helix-helix protein, CopG family-
ALW85_RS02515 (NE0476)516603..516857+255WP_011111107.1type II toxin-antitoxin system RelE/ParE family toxin-
ALW85_RS13875517180..517371+192WP_143023752.1type II toxin-antitoxin system RelE/ParE family toxin-
ALW85_RS02520 (NE0477)517316..519226-1911WP_011111108.1ATP-binding cassette domain-containing protein-
ALW85_RS02525 (NE0478)519527..519760+234WP_011111109.1antitoxinAntitoxin
ALW85_RS02530 (NE0479)519760..520161+402WP_011111110.1type II toxin-antitoxin system VapC family toxinToxin
ALW85_RS02535 (NE0480)520320..520748+429WP_011111111.1hypothetical protein-
ALW85_RS02540 (NE0481)520813..521118-306WP_011111112.1HigA family addiction module antidote protein-
ALW85_RS02545 (NE0482)521128..521406-279WP_041357019.1type II toxin-antitoxin system RelE/ParE family toxin-
ALW85_RS02550 (NE0483)521508..522863+1356WP_011111114.1ABC transporter ATP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(9-56)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15343.62 Da        Isoelectric Point: 7.4204

>T20953 WP_011111110.1 NC_004757:519760-520161 [Nitrosomonas europaea ATCC 19718]
MLKYMLDTNIAIYVIKRRPIEVLVTFNRYADMMCVSAVTEAELLHGAEKSRQREHNLRQVADFLSRLEVLSYTSKAAGHY
GDIRADLERKEKPIGVNDLHIAAHARSEGFILVSNNLREFERVDGLRLENWIT

Download         Length: 402 bp

>T20953 NC_004757:519760-520161 [Nitrosomonas europaea ATCC 19718]
ATGCTCAAATATATGCTGGATACGAACATCGCCATCTACGTTATCAAACGTCGGCCAATAGAAGTGCTGGTTACCTTTAA
CCGCTATGCAGACATGATGTGCGTAAGCGCTGTTACCGAAGCCGAGTTACTGCACGGCGCAGAAAAAAGCCGGCAGCGTG
AGCACAATCTGCGACAGGTGGCTGATTTTTTATCTCGTCTGGAAGTGCTGTCGTATACCAGTAAAGCAGCCGGGCATTAT
GGTGATATTCGTGCTGATCTGGAGCGAAAAGAAAAGCCCATCGGCGTGAATGACTTGCACATCGCCGCTCATGCTCGCAG
TGAAGGTTTCATCCTGGTCAGTAATAACCTGCGTGAATTTGAACGAGTAGATGGTTTGCGTTTGGAAAATTGGATTACCT
GA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9077.16 Da        Isoelectric Point: 4.8096

>AT20953 WP_011111109.1 NC_004757:519527-519760 [Nitrosomonas europaea ATCC 19718]
MYTGTVFENNRTQAVRLPVDVRFADDVKKVWVRKLGKERILTPVDHTWDSFFLAEQGVSEDFLSERASQEQQEREVF

Download         Length: 234 bp

>AT20953 NC_004757:519527-519760 [Nitrosomonas europaea ATCC 19718]
ATGTATACAGGTACTGTTTTTGAAAATAACCGTACTCAGGCTGTACGTTTGCCGGTAGATGTGCGCTTTGCCGATGATGT
GAAAAAGGTCTGGGTACGTAAACTGGGTAAAGAGCGAATCCTGACCCCGGTTGACCATACTTGGGACAGCTTTTTTCTGG
CGGAACAAGGTGTTTCAGAAGATTTTTTATCTGAACGTGCCAGTCAGGAGCAGCAGGAGCGCGAGGTGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBQ82X22

References