Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4935857..4936373 Replicon chromosome
Accession NZ_CP079617
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC16_AI1547MC

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KW551_RS24300 Protein ID WP_040216106.1
Coordinates 4935857..4936141 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KW551_RS24305 Protein ID WP_064162488.1
Coordinates 4936131..4936373 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW551_RS24275 (4931274) 4931274..4931537 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
KW551_RS24280 (4931667) 4931667..4931840 + 174 WP_032425422.1 hypothetical protein -
KW551_RS24285 (4931843) 4931843..4932586 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KW551_RS24290 (4932943) 4932943..4935081 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KW551_RS24295 (4935389) 4935389..4935853 + 465 WP_064162487.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KW551_RS24300 (4935857) 4935857..4936141 - 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KW551_RS24305 (4936131) 4936131..4936373 - 243 WP_064162488.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KW551_RS24310 (4936451) 4936451..4938361 - 1911 WP_023325426.1 PRD domain-containing protein -
KW551_RS24315 (4938384) 4938384..4939538 - 1155 WP_064162489.1 lactonase family protein -
KW551_RS24320 (4939605) 4939605..4940345 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T209523 WP_040216106.1 NZ_CP079617:c4936141-4935857 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T209523 NZ_CP104123:1932836-1933090 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9059.57 Da        Isoelectric Point: 6.3340

>AT209523 WP_064162488.1 NZ_CP079617:c4936373-4936131 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT209523 NZ_CP104123:1932588-1932839 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References