Detailed information of TA system TA020952

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 296385..296921
• Replicon: chromosome
• Accession: NC_004757
• Organism: Nitrosomonas europaea ATCC 19718

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q82XK4
• Locus tag: ALW85_RS01380
• Protein ID: WP_011110900.1
• Coordinates: 296385..296678 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: ALW85_RS01385
• Protein ID: WP_011110901.1
• Coordinates: 296679..296921 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ALW85_RS01355 (RK28_RS01360)	292989..293177	-	189	WP_041356354.1	hypothetical protein	-
ALW85_RS01360 (NE0257)	293167..293775	-	609	WP_041356959.1	recombinase family protein	-
ALW85_RS01365 (NE0258)	294019..294411	+	393	WP_011110897.1	hypothetical protein	-
ALW85_RS01370 (NE0259)	294413..295210	-	798	WP_011110898.1	hypothetical protein	-
ALW85_RS13830	295203..295382	-	180	WP_143023785.1	hypothetical protein	-
ALW85_RS01375 (NE0260)	295737..296252	+	516	WP_011110899.1	antirestriction protein ArdA	-
ALW85_RS01380 (NE0261)	296385..296678	-	294	WP_011110900.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ALW85_RS01385 (NE0262)	296679..296921	-	243	WP_011110901.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
ALW85_RS01395 (NE0263)	297241..297603	+	363	WP_078737694.1	metalloregulator ArsR/SmtB family transcription factor	-
ALW85_RS01400 (NE0264)	297584..298096	+	513	WP_011110903.1	SRPBCC family protein	-
ALW85_RS13470 (NE0265)	298118..298369	+	252	WP_011110904.1	YdeI/OmpD-associated family protein	-
ALW85_RS01410 (NE0266)	298392..298871	+	480	WP_011110905.1	VOC family protein	-
ALW85_RS01415 (NE0267)	298950..299336	+	387	WP_011110906.1	DUF1428 domain-containing protein	-
ALW85_RS01420 (NE0268)	299643..300686	-	1044	WP_011110833.1	IS481 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Antitoxin ParD (4-77)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11464.22 Da
• Isoelectric Point: 9.7308

>T20952 WP_011110900.1 NC_004757:c296678-296385 [Nitrosomonas europaea ATCC 19718]
MGSFILRQKAMDDLLSIGRYTRKEWGKTQQIRYLTQLDRAFHELADKPGLGRACDDIREGYFKYGVGKHVIFYRHTGKDQ
IEIIRILHGRMDIEQHL

Nucleotide

• Length: 294 bp

>T20952 NC_004757:c296678-296385 [Nitrosomonas europaea ATCC 19718]
ATGGGATCGTTTATCCTCAGGCAGAAAGCAATGGATGATTTACTGTCCATTGGCCGCTACACCCGAAAAGAATGGGGAAA
AACCCAACAAATCCGCTATCTGACACAGCTTGACCGTGCATTTCATGAACTGGCGGACAAGCCCGGTCTGGGCCGGGCGT
GTGATGATATCCGGGAAGGCTATTTCAAGTATGGGGTTGGTAAACATGTCATTTTTTACCGTCATACTGGAAAAGACCAA
ATTGAGATTATCCGTATCTTGCATGGCCGTATGGATATCGAACAGCATTTGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8868.89 Da
• Isoelectric Point: 4.5158

>AT20952 WP_011110901.1 NC_004757:c296921-296679 [Nitrosomonas europaea ATCC 19718]
MPIQKNTSVTLGEHFEKFLAHQIEAGRYGSASEAIRAGLRLLEEREAKLEALRRALIEGEQSGPADYSLQNVLDELESAD

Nucleotide

• Length: 243 bp

>AT20952 NC_004757:c296921-296679 [Nitrosomonas europaea ATCC 19718]
ATGCCGATACAAAAAAATACCAGTGTCACGCTGGGCGAGCATTTTGAGAAGTTTCTTGCACATCAGATTGAAGCCGGGCG
CTACGGCTCGGCAAGTGAAGCGATCCGCGCGGGGCTGCGTCTGCTGGAAGAACGCGAGGCCAAGCTGGAAGCATTACGCC
GTGCCCTGATCGAGGGCGAGCAAAGCGGCCCGGCTGATTATTCCCTGCAAAATGTTCTGGATGAGCTGGAAAGTGCAGAC
TAG

Structures

Toxin

• AlphaFold DB: Q82XK4