Detailed information of TA system TA209497

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3849437..3850094
• Replicon: chromosome
• Accession: NZ_CP079606
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC15_AI1547PC

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KW550_RS18725
• Protein ID: WP_040245400.1
• Coordinates: 3849684..3850094 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: KW550_RS18720
• Protein ID: WP_002916312.1
• Coordinates: 3849437..3849703 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KW550_RS18695 (3844593)	3844593..3846026	-	1434	WP_002916322.1	6-phospho-beta-glucosidase BglA	-
KW550_RS18700 (3846145)	3846145..3846873	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
KW550_RS18705 (3846923)	3846923..3847234	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
KW550_RS18710 (3847398)	3847398..3848057	+	660	WP_048334397.1	hemolysin III family protein	-
KW550_RS18715 (3848208)	3848208..3849191	-	984	WP_032430613.1	tRNA-modifying protein YgfZ	-
KW550_RS18720 (3849437)	3849437..3849703	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
KW550_RS18725 (3849684)	3849684..3850094	+	411	WP_040245400.1	protein YgfX	Toxin
KW550_RS18730 (3850101)	3850101..3850622	-	522	WP_002916308.1	flavodoxin FldB	-
KW550_RS18735 (3850723)	3850723..3851619	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
KW550_RS18740 (3851642)	3851642..3852355	+	714	WP_048290928.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
KW550_RS18745 (3852361)	3852361..3854094	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16035.83 Da
• Isoelectric Point: 11.4778

>T209497 WP_040245400.1 NZ_CP079606:3849684-3850094 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T209497 NZ_CP104117:2148014-2148117 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT209497 WP_002916312.1 NZ_CP079606:3849437-3849703 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT209497 NZ_CP104117:c2148155-2147884 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41