Detailed information of TA system TA209468

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 2783077..2784029
• Replicon: chromosome
• Accession: NZ_CP079225
• Organism: Rhodococcus sp. LW-XY12

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: KXC42_RS12965
• Protein ID: WP_219129119.1
• Coordinates: 2783077..2783646 (-)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: V9X925
• Locus tag: KXC42_RS12970
• Protein ID: WP_024101066.1
• Coordinates: 2783643..2784029 (-)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXC42_RS12965 (KXC42_12950)	2783077..2783646	-	570	WP_219129119.1	zeta toxin family protein	Toxin
KXC42_RS12970 (KXC42_12955)	2783643..2784029	-	387	WP_024101066.1	hypothetical protein	Antitoxin
KXC42_RS12975 (KXC42_12960)	2784236..2785306	+	1071	WP_138843340.1	methyltransferase domain-containing protein	-
KXC42_RS12980 (KXC42_12965)	2785376..2785741	+	366	WP_024101068.1	HNH endonuclease	-
KXC42_RS12985 (KXC42_12970)	2786973..2787734	-	762	WP_219129120.1	hypothetical protein	-
KXC42_RS12990 (KXC42_12975)	2787839..2787991	+	153	WP_219129121.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (7-102)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 20550.73 Da
• Isoelectric Point: 10.6895

>T209468 WP_219129119.1 NZ_CP079225:c2783646-2783077 [Rhodococcus sp. LW-XY12]
MRRLDLIVGPNGSGKSTFVELSLAPLLPRSVFVNADVIARQRWPDRAEEMSYEAAQLAAAARDRLLRQGRSFIAETVFSH
PSKLELIDRAHEVGFTVVLHVMLVPEAMSVLRVQHRVASGGHAVPEDKIRARYRRLWPLVAEAIGRADQASVYDTASGTP
VVVARFAGGVPVGVVRWPGWAPAALTGLG

Nucleotide

• Length: 570 bp

>T209468 NZ_CP104113:145668-146018 [Escherichia coli]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 13980.46 Da
• Isoelectric Point: 4.8349

>AT209468 WP_024101066.1 NZ_CP079225:c2784029-2783643 [Rhodococcus sp. LW-XY12]
MTSSTDKVTRFDAELVDSAIAEGGRQNRTGRQQLEYWARIGRAMTAHETASLHRVHEALAGTRELSELTAAEGRLFDAEI
DARLAGGLARTDYAEVLAARGVTTVVLDDEGRLVEQRPDGSRRVLDDA

Nucleotide

• Length: 387 bp

>AT209468 NZ_CP104113:146023-146325 [Escherichia coli]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Structures

Antitoxin

• AlphaFold DB: V9X925