Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 20318..21105 Replicon plasmid pZM33
Accession NZ_CP079223
Organism Zymomonas mobilis strain ZM401

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag KXD87_RS09545 Protein ID WP_062339594.1
Coordinates 20318..20812 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag KXD87_RS09550 Protein ID WP_062339592.1
Coordinates 20809..21105 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXD87_RS09530 16092..17387 - 1296 WP_062339600.1 C4-dicarboxylate transporter DctA -
KXD87_RS09535 17404..18837 - 1434 WP_108125217.1 carbohydrate porin -
KXD87_RS09540 19060..19965 + 906 WP_062339596.1 LysR family transcriptional regulator -
KXD87_RS09545 20318..20812 - 495 WP_062339594.1 GNAT family N-acetyltransferase Toxin
KXD87_RS09550 20809..21105 - 297 WP_062339592.1 DUF1778 domain-containing protein Antitoxin
KXD87_RS09555 21302..21952 + 651 WP_062339590.1 AAA family ATPase -
KXD87_RS09560 21982..22242 + 261 WP_062339589.1 ribbon-helix-helix protein, CopG family -
KXD87_RS09565 22376..22957 - 582 WP_062339588.1 AAA family ATPase -
KXD87_RS09570 22954..23190 - 237 WP_062339585.1 hypothetical protein -
KXD87_RS09575 23957..24337 - 381 WP_062339584.1 type II toxin-antitoxin system death-on-curing family toxin -
KXD87_RS09580 24334..24564 - 231 WP_062339583.1 hypothetical protein -
KXD87_RS09585 25024..25353 - 330 WP_062339581.1 DUF1870 family protein -
KXD87_RS09590 25354..25704 - 351 WP_062339579.1 helix-turn-helix domain-containing protein -
KXD87_RS09595 25692..25970 - 279 WP_062339577.1 BrnT family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33006 33006


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-144)

Antitoxin

Vibrio phage ICP1, Orf50

(16-90)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 17994.99 Da        Isoelectric Point: 9.9205

>T209465 WP_062339594.1 NZ_CP079223:c20812-20318 [Zymomonas mobilis]
VTITAPELVSPEHQVDLFQSGVESLDLWLKKRALKNQMTGASRTFVACKNRRVIAYYALASSAITIKSAHGRFRRNMPDP
IPVVVLGRLAIDQSLHNQGVGRAMVRDAALRIIQAADTIGIRGMLVHALSDEAKSFYEHIGFEPSPIDPMMLMVTLADLK
SSLA

Download         Length: 495 bp

>T209465 NZ_CP104112:c4309308-4309201 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11258.00 Da        Isoelectric Point: 7.7936

>AT209465 WP_062339592.1 NZ_CP079223:c21105-20809 [Zymomonas mobilis]
MTAATTIPSPNKREALNIRIKPEERDLIDRAAKIQRKSRTNFVLEAACRAAEEALFDQCLISVDPKAYTDFLMRLDMPPR
PNDRLQKTMQTVAPWDEL

Download         Length: 297 bp

>AT209465 NZ_CP104112:4309356-4309422 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References