Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 313432..314285 Replicon chromosome
Accession NZ_CP079202
Organism Bifidobacterium longum subsp. suillum strain KCTC 15605

Toxin (Protein)


Gene name relE Uniprot ID A0A7L9UL57
Locus tag BLS605_RS01535 Protein ID WP_029679475.1
Coordinates 313432..313923 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V6XX41
Locus tag BLS605_RS01540 Protein ID WP_008783109.1
Coordinates 313923..314285 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLS605_RS01515 (BLS605_01515) 309172..310071 - 900 WP_197308794.1 Bax inhibitor-1/YccA family protein -
BLS605_RS01520 (BLS605_01520) 310355..310495 + 141 Protein_303 LuxR C-terminal-related transcriptional regulator -
BLS605_RS01525 (BLS605_01525) 310536..311177 + 642 WP_029679476.1 GNAT family N-acetyltransferase -
BLS605_RS01530 (BLS605_01530) 311266..313371 + 2106 WP_013140894.1 DUF262 domain-containing protein -
BLS605_RS01535 (BLS605_01535) 313432..313923 - 492 WP_029679475.1 PIN domain-containing protein Toxin
BLS605_RS01540 (BLS605_01540) 313923..314285 - 363 WP_008783109.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BLS605_RS01545 (BLS605_01545) 314431..317130 - 2700 WP_197308795.1 aconitate hydratase AcnA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18370.95 Da        Isoelectric Point: 4.5590

>T209459 WP_029679475.1 NZ_CP079202:c313923-313432 [Bifidobacterium longum subsp. suillum]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCVSLSLKDIAYLSSSAIRREFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDRAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Download         Length: 492 bp

>T209459 NZ_CP104112:c2748615-2748364 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13974.03 Da        Isoelectric Point: 5.0733

>AT209459 WP_008783109.1 NZ_CP079202:c314285-313923 [Bifidobacterium longum subsp. suillum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDAYYNMKRAD

Download         Length: 363 bp

>AT209459 NZ_CP104112:c2748367-2748113 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L9UL57

Antitoxin

Source ID Structure
AlphaFold DB V6XX41

References