Detailed information of TA system TA209457

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 1953746..1954271
• Replicon: chromosome
• Accession: NZ_CP079193
• Organism: Streptococcus suis strain ID41570

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G7SEL6
• Locus tag: KWY62_RS09425
• Protein ID: WP_014638724.1
• Coordinates: 1953746..1954075 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: KWY62_RS09430
• Protein ID: WP_238492611.1
• Coordinates: 1954065..1954271 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KWY62_RS09405 (KWY62_09405)	1949096..1950826	-	1731	WP_041179291.1	membrane protein	-
KWY62_RS09410 (KWY62_09410)	1951029..1951901	-	873	WP_014638721.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
KWY62_RS09415 (KWY62_09415)	1952079..1953248	-	1170	WP_014638722.1	hypothetical protein	-
KWY62_RS09420 (KWY62_09420)	1953265..1953648	-	384	WP_014638723.1	DUF2513 domain-containing protein	-
KWY62_RS09425 (KWY62_09425)	1953746..1954075	-	330	WP_014638724.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KWY62_RS09430 (KWY62_09430)	1954065..1954271	-	207	WP_238492611.1	toxin-antitoxin system antitoxin subunit	Antitoxin
KWY62_RS09435 (KWY62_09435)	1954450..1954818	-	369	WP_024401195.1	hypothetical protein	-
KWY62_RS09440 (KWY62_09440)	1954811..1955380	-	570	WP_105105440.1	ribonuclease M5	-
KWY62_RS09445 (KWY62_09445)	1955364..1956146	-	783	WP_105105439.1	TatD family hydrolase	-
KWY62_RS09450 (KWY62_09450)	1956253..1956390	-	138	WP_002939016.1	50S ribosomal protein L34	-
KWY62_RS09455 (KWY62_09455)	1956558..1957553	-	996	WP_024395756.1	RNA-binding cell elongation regulator Jag/EloR	-
KWY62_RS09460 (KWY62_09460)	1957573..1958385	-	813	WP_202847568.1	YidC/Oxa1 family membrane protein insertase	-
KWY62_RS09465 (KWY62_09465)	1958369..1958728	-	360	WP_004194560.1	ribonuclease P protein component	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-96)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12607.51 Da
• Isoelectric Point: 5.7640

>T209457 WP_014638724.1 NZ_CP079193:c1954075-1953746 [Streptococcus suis]
MEFESYSVILAPAVEKELADIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVIGKD
YIALYRVVEKEVRVGHLFATKSDYVKLLK

Nucleotide

• Length: 330 bp

>T209457 NZ_CP104112:c2559236-2559133 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7816.90 Da
• Isoelectric Point: 3.9249

>AT209457 WP_238492611.1 NZ_CP079193:c1954271-1954065 [Streptococcus suis]
MNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEAGQGISLEIVKEKYGI

Nucleotide

• Length: 207 bp

>AT209457 NZ_CP104112:2559095-2559366 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: G7SEL6