Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1479969..1480617 Replicon chromosome
Accession NZ_CP079193
Organism Streptococcus suis strain ID41570

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KWY62_RS07255 Protein ID WP_044679833.1
Coordinates 1480456..1480617 (-) Length 54 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G7SGM2
Locus tag KWY62_RS07250 Protein ID WP_014637654.1
Coordinates 1479969..1480418 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWY62_RS07235 (KWY62_07235) 1475627..1477558 - 1932 WP_202847630.1 C69 family dipeptidase -
KWY62_RS07240 (KWY62_07240) 1477751..1478611 - 861 WP_044762617.1 SAM-dependent methyltransferase TehB -
KWY62_RS07245 (KWY62_07245) 1478765..1479808 + 1044 WP_202847719.1 alcohol dehydrogenase catalytic domain-containing protein -
KWY62_RS07250 (KWY62_07250) 1479969..1480418 - 450 WP_014637654.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KWY62_RS07255 (KWY62_07255) 1480456..1480617 - 162 WP_044679833.1 type II toxin-antitoxin system HicA family toxin Toxin
KWY62_RS07260 (KWY62_07260) 1481004..1481222 - 219 WP_228475258.1 hypothetical protein -
KWY62_RS07265 (KWY62_07265) 1481533..1482390 - 858 WP_052502457.1 ABC transporter ATP-binding protein -
KWY62_RS07270 (KWY62_07270) 1482392..1483075 - 684 WP_218981848.1 hypothetical protein -
KWY62_RS07275 (KWY62_07275) 1483478..1483945 - 468 WP_014637647.1 SsrA-binding protein SmpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(1-52)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 5807.85 Da        Isoelectric Point: 10.9132

>T209456 WP_044679833.1 NZ_CP079193:c1480617-1480456 [Streptococcus suis]
MVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 162 bp

>T209456 NZ_CP104112:c2232884-2231562 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16664.69 Da        Isoelectric Point: 3.9458

>AT209456 WP_014637654.1 NZ_CP079193:c1480418-1479969 [Streptococcus suis]
MLVTYPALFYFDDTDGANAPYFVTFPDFEYSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
RNEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 450 bp

>AT209456 NZ_CP104112:c2233150-2232884 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G7SGM2

References