Detailed information of TA system TA209455

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1197021..1198453
• Replicon: chromosome
• Accession: NZ_CP079193
• Organism: Streptococcus suis strain ID41570

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: KWY62_RS05940
• Protein ID: WP_218981832.1
• Coordinates: 1197608..1198453 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: A0A0Z8TLJ4
• Locus tag: KWY62_RS05935
• Protein ID: WP_000037243.1
• Coordinates: 1197021..1197611 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KWY62_RS05935 (KWY62_05935)	1197021..1197611	+	591	WP_000037243.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
KWY62_RS05940 (KWY62_05940)	1197608..1198453	+	846	WP_218981832.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KWY62_RS05945 (KWY62_05945)	1198539..1198823	-	285	Protein_1133	CHAP domain-containing protein	-
KWY62_RS05950 (KWY62_05950)	1198937..1199947	-	1011	WP_002936451.1	Abi family protein	-
KWY62_RS05955 (KWY62_05955)	1200084..1202885	-	2802	WP_015445150.1	phage tail tip lysozyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(O) / erm(B)	-	1068571..1313015	244444

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-257)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32480.10 Da
• Isoelectric Point: 4.8302

>T209455 WP_218981832.1 NZ_CP079193:1197608-1198453 [Streptococcus suis]
MNKANLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRVTILCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFEKIIELLERFKSDP
IQNKQWQNYSKKYSYTKVISLADVLDEMISLITIIISTDSD

Nucleotide

• Length: 846 bp

>T209455 NZ_CP104112:2144593-2144769 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23237.83 Da
• Isoelectric Point: 8.3384

>AT209455 WP_000037243.1 NZ_CP079193:1197021-1197611 [Streptococcus suis]
MSKKEILLEFIEKHKGIITYKDCKALNIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVNTPMGNEVRAYDFERIICDFVIHREKIDTELFVKT
LQHYGNYPKKNLTKLYEYATKMNTLAKVKQTLEVLV

Nucleotide

• Length: 591 bp

>AT209455 NZ_CP104112:2144815-2145231 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0Z8TLJ4