Detailed information of TA system TA209454

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-couple_hipB
• Location: 1166197..1167440
• Replicon: chromosome
• Accession: NZ_CP079193
• Organism: Streptococcus suis strain ID41570

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: G7SEB4
• Locus tag: KWY62_RS05775
• Protein ID: WP_001235242.1
• Coordinates: 1166197..1166964 (-)
• Length: 256 a.a.

Antitoxin (Protein)

• Gene name: sezA
• Uniprot ID: -
• Locus tag: KWY62_RS05780
• Protein ID: WP_000578719.1
• Coordinates: 1166964..1167440 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KWY62_RS05760 (KWY62_05760)	1162585..1162950	-	366	WP_000431640.1	MobC family plasmid mobilization relaxosome protein	-
KWY62_RS05765 (KWY62_05765)	1162953..1163315	-	363	WP_000140674.1	SAG1252 family conjugative relaxosome accessory protein	-
KWY62_RS05770 (KWY62_05770)	1163653..1166196	-	2544	WP_000601012.1	AAA family ATPase	-
KWY62_RS05775 (KWY62_05775)	1166197..1166964	-	768	WP_001235242.1	type II toxin-antitoxin system toxin PezT	Toxin
KWY62_RS05780 (KWY62_05780)	1166964..1167440	-	477	WP_000578719.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
KWY62_RS05785 (KWY62_05785)	1167510..1167800	-	291	WP_000667951.1	hypothetical protein	-
KWY62_RS05790 (KWY62_05790)	1167850..1168239	-	390	WP_044475264.1	DUF5945 family protein	-
KWY62_RS05795 (KWY62_05795)	1168236..1168463	-	228	WP_000110922.1	DUF5965 family protein	-
KWY62_RS05800 (KWY62_05800)	1168491..1169591	-	1101	WP_014636297.1	toprim domain-containing protein	-
KWY62_RS05805 (KWY62_05805)	1169631..1170269	-	639	WP_218981827.1	peptidylprolyl isomerase	-
KWY62_RS05810 (KWY62_05810)	1170364..1170654	-	291	WP_000893083.1	DUF5966 family protein	-
KWY62_RS05815 (KWY62_05815)	1170668..1170967	-	300	WP_014636295.1	DUF5962 family protein	-
KWY62_RS05820 (KWY62_05820)	1171038..1171997	-	960	Protein_1108	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(O) / erm(B)	-	1068571..1313015	244444

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 256 a.a.
• Molecular weight: 28985.80 Da
• Isoelectric Point: 5.1126

>T209454 WP_001235242.1 NZ_CP079193:c1166964-1166197 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK

Nucleotide

• Length: 768 bp

>T209454 NZ_CP104112:c1942043-1941936 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18266.77 Da
• Isoelectric Point: 4.6424

>AT209454 WP_000578719.1 NZ_CP079193:c1167440-1166964 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT209454 NZ_CP104112:1942090-1942156 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: G7SEB4