209453

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 967634..968135 Replicon chromosome
Accession NZ_CP079193
Organism Streptococcus suis strain ID41570

Toxin (Protein)


Gene name relE Uniprot ID G7SDZ6
Locus tag KWY62_RS04860 Protein ID WP_014637925.1
Coordinates 967869..968135 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A116L3F7
Locus tag KWY62_RS04855 Protein ID WP_024385716.1
Coordinates 967634..967885 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWY62_RS04830 (KWY62_04830) 962961..964127 + 1167 WP_202847705.1 ATP-grasp domain-containing protein -
KWY62_RS04835 (KWY62_04835) 964268..964408 + 141 WP_044683303.1 hypothetical protein -
KWY62_RS04840 (KWY62_04840) 964421..964792 + 372 WP_202847704.1 NisI/SpaI family lantibiotic immunity lipoprotein -
KWY62_RS04845 (KWY62_04845) 964820..965572 + 753 WP_015646831.1 ATP-binding cassette domain-containing protein -
KWY62_RS04850 (KWY62_04850) 965573..967543 + 1971 WP_202847703.1 ABC transporter permease -
KWY62_RS04855 (KWY62_04855) 967634..967885 + 252 WP_024385716.1 DUF6290 family protein Antitoxin
KWY62_RS04860 (KWY62_04860) 967869..968135 + 267 WP_014637925.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KWY62_RS04865 (KWY62_04865) 968174..968842 + 669 WP_024413648.1 response regulator transcription factor -
KWY62_RS04870 (KWY62_04870) 968839..969780 + 942 WP_024413647.1 sensor histidine kinase -
KWY62_RS04875 (KWY62_04875) 969961..971469 + 1509 WP_202847702.1 phosphomannomutase/phosphoglucomutase -
KWY62_RS04880 (KWY62_04880) 971532..972602 - 1071 WP_202847701.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10345.99 Da        Isoelectric Point: 10.7260

>T209453 WP_014637925.1 NZ_CP079193:967869-968135 [Streptococcus suis]
MKTSYKLVPTGRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

>T209453 NZ_CP104112:c1941509-1941402 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9296.46 Da        Isoelectric Point: 3.6675

>AT209453 WP_024385716.1 NZ_CP079193:967634-967885 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALAEYEADLANGIEPISWEEMLEDLGLTDE
DQL

Download         Length: 252 bp

>AT209453 NZ_CP104112:1941556-1941621 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7SDZ6

Antitoxin

Source ID Structure
AlphaFold DB A0A116L3F7

References