Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4855024..4855540 Replicon chromosome
Accession NZ_CP079179
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC13_AI2040PC

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KWY86_RS23680 Protein ID WP_040216106.1
Coordinates 4855024..4855308 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KWY86_RS23685 Protein ID WP_064162488.1
Coordinates 4855298..4855540 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWY86_RS23655 (4850441) 4850441..4850704 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
KWY86_RS23660 (4850834) 4850834..4851007 + 174 WP_032425422.1 hypothetical protein -
KWY86_RS23665 (4851010) 4851010..4851753 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KWY86_RS23670 (4852110) 4852110..4854248 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KWY86_RS23675 (4854556) 4854556..4855020 + 465 WP_064162487.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KWY86_RS23680 (4855024) 4855024..4855308 - 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KWY86_RS23685 (4855298) 4855298..4855540 - 243 WP_064162488.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KWY86_RS23690 (4855618) 4855618..4857528 - 1911 WP_023325426.1 PRD domain-containing protein -
KWY86_RS23695 (4857551) 4857551..4858705 - 1155 WP_125297151.1 lactonase family protein -
KWY86_RS23700 (4858772) 4858772..4859512 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T209429 WP_040216106.1 NZ_CP079179:c4855308-4855024 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T209429 NZ_CP104108:762933-763349 [Cronobacter sakazakii]
GTGGTCCTGTGGCACTCTGATCTTCGCGTTTCATGGCGCTCGCAGTGGCTATCGCTGCTGCTGCACGGCGCCGTGGCCGT
TATTATTTTGCTGCTCCCCTGGCCGCTGCGGTATCTGCCCGTGTGGATGCTGTTGCTGTCTCTGGTGGTGTTTGACTGCG
TACGTAGCCAGCGGCGTATCAATGCGTTTCAGGGCGAGGTCAGCCTGACGGCTGATTATCACCTTCGCTGGCAGGGCGTT
GACTGGCAGATTTGCGCCACGCCCTGGATGCTGCGCAGCGGAATGATGCTGCGGCTGCGTCATCCTAAAACGACACGCCG
CCATCATGTCTGGCTGGCGGCGGATAGCATGACGGAAGCGGAGTGGCGCGATTTGCGTCGCCTTCTGTTGCAACAGCCCG
TAGGCGACAAACGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9059.57 Da        Isoelectric Point: 6.3340

>AT209429 WP_064162488.1 NZ_CP079179:c4855540-4855298 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT209429 NZ_CP104108:762686-762952 [Cronobacter sakazakii]
ATGGATATTAATAATAAAGCCCGTATTCACTGGGCATGTCGCAGAGGTATGCGCGAGCTGGATATTTCCATCATGCCTTT
CTTTGAATATGACTATGACTCCCTGAGCGACGAAGACAAACGCGTTTTTGTCCGCCTGCTGGAGTGTGACGATCCTGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCAGCTGATGCGGAGCTGGCGCGAATGGTGGAATTAATCCAGCAGCGGAAT
CAGGCACGTGGTCCTGTGGCACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References