Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4933496..4934012 Replicon chromosome
Accession NZ_CP079172
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC11_S471PC

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KWY79_RS24245 Protein ID WP_040216106.1
Coordinates 4933496..4933780 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KWY79_RS24250 Protein ID WP_064162488.1
Coordinates 4933770..4934012 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWY79_RS24220 (4928913) 4928913..4929176 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
KWY79_RS24225 (4929306) 4929306..4929479 + 174 WP_032425422.1 hypothetical protein -
KWY79_RS24230 (4929482) 4929482..4930225 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KWY79_RS24235 (4930582) 4930582..4932720 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KWY79_RS24240 (4933028) 4933028..4933492 + 465 WP_064162487.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KWY79_RS24245 (4933496) 4933496..4933780 - 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KWY79_RS24250 (4933770) 4933770..4934012 - 243 WP_064162488.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KWY79_RS24255 (4934090) 4934090..4936000 - 1911 WP_023325426.1 PRD domain-containing protein -
KWY79_RS24260 (4936023) 4936023..4937177 - 1155 WP_064162489.1 lactonase family protein -
KWY79_RS24265 (4937244) 4937244..4937984 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T209410 WP_040216106.1 NZ_CP079172:c4933780-4933496 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T209410 NZ_CP104078:154232-154381 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9059.57 Da        Isoelectric Point: 6.3340

>AT209410 WP_064162488.1 NZ_CP079172:c4934012-4933770 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT209410 NZ_CP104078:c154188-154127 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References