Detailed information of TA system TA209406

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2772996..2774584
• Replicon: chromosome
• Accession: NZ_CP079172
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC11_S471PC

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KWY79_RS13695
• Protein ID: WP_064162061.1
• Coordinates: 2772996..2774318 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: KWY79_RS13700
• Protein ID: WP_002904790.1
• Coordinates: 2774318..2774584 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KWY79_RS13680 (2768052)	2768052..2770553	+	2502	WP_064162059.1	fimbria/pilus outer membrane usher protein	-
KWY79_RS13685 (2770541)	2770541..2771545	+	1005	WP_064162060.1	fimbrial protein	-
KWY79_RS13690 (2771687)	2771687..2772979	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
KWY79_RS13695 (2772996)	2772996..2774318	-	1323	WP_064162061.1	type II toxin-antitoxin system HipA family toxin	Toxin
KWY79_RS13700 (2774318)	2774318..2774584	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KWY79_RS13705 (2774850)	2774850..2775176	-	327	WP_064162062.1	hydroxyisourate hydrolase	-
KWY79_RS13710 (2775173)	2775173..2775673	-	501	WP_064162063.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
KWY79_RS13715 (2775651)	2775651..2777030	-	1380	WP_040245186.1	nucleobase:cation symporter-2 family protein	-
KWY79_RS13720 (2777376)	2777376..2778530	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
KWY79_RS13725 (2778511)	2778511..2779434	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49155.46 Da
• Isoelectric Point: 7.5357

>T209406 WP_064162061.1 NZ_CP079172:c2774318-2772996 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T209406 NZ_CP104077:c4492698-4492324 [Escherichia coli]
ATGGCAAAAAGAACTGCGCTTTTTGATACCAATATCCTTATCGATTTGTTCAGCGGACGAATTGAGGCAAAACAGGCTCT
GGAGGCATGGCCCCTACAGAATGCGATTAGTCTGGTCACATGGATGGAGGTGCTGGTTGGCGCAAAAAAATATGATCAAG
AACATCGCACACGGATTGCAATGAGTGCGTTTAACGTTATTGGGATTTCGCAGGATATCGCGGAACGAAGCGTTGCTTTA
AGGCAGGAGTATAGAATGAAACTTCCAGATGCCATTATTCTGGCAACAGCACAGATTTATGGCTTTGAACTGGTAACGCG
AAATACGAGAGATTTTGCGGGAATAGCAGGTGTCGTCACACCCTATGAGCTGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT209406 WP_002904790.1 NZ_CP079172:c2774584-2774318 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT209406 NZ_CP104077:c4492940-4492698 [Escherichia coli]
ATGAGCGCTATGGCAGGTATGGATATGGGCAGAATTTTACTCGATTTATCCGATGAGGTGATTAAGCGACTTGATGATCT
CAAAGTGCAGCGCAATCTTCCTCGCGCAGAGCTATTACGAGAAGCTGTAGATCAATATCTGGAAAATCAATCGAAAACGA
CAATATCCAGTGCTTTTGGTATCTGGCAAGGGTGTGAGGAAGATGGTGTCGAATATCAGCGTAAGCTGCGTGAGGAATGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8