Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4706239..4707827 Replicon chromosome
Accession NZ_CP079164
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC09_CMC309PC

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KWY74_RS22480 Protein ID WP_004179815.1
Coordinates 4706505..4707827 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KWY74_RS22475 Protein ID WP_004176198.1
Coordinates 4706239..4706505 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWY74_RS22450 (4701389) 4701389..4702312 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
KWY74_RS22455 (4702293) 4702293..4703447 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
KWY74_RS22460 (4703793) 4703793..4705172 + 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
KWY74_RS22465 (4705150) 4705150..4705650 + 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
KWY74_RS22470 (4705647) 4705647..4705973 + 327 WP_002904788.1 hydroxyisourate hydrolase -
KWY74_RS22475 (4706239) 4706239..4706505 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KWY74_RS22480 (4706505) 4706505..4707827 + 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
KWY74_RS22485 (4707844) 4707844..4709136 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
KWY74_RS22490 (4709278) 4709278..4710282 - 1005 WP_218394504.1 fimbrial protein -
KWY74_RS22495 (4710270) 4710270..4712771 - 2502 WP_004179823.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T209394 WP_004179815.1 NZ_CP079164:4706505-4707827 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T209394 NZ_CP104077:c2024429-2024322 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT209394 WP_004176198.1 NZ_CP079164:4706239-4706505 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT209394 NZ_CP104077:2024482-2024543 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References