Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1285194..1285851 Replicon chromosome
Accession NZ_CP079164
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC09_CMC309PC

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag KWY74_RS06180 Protein ID WP_004181233.1
Coordinates 1285194..1285604 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KWY74_RS06185 Protein ID WP_002916312.1
Coordinates 1285585..1285851 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWY74_RS06160 (1281194) 1281194..1282927 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
KWY74_RS06165 (1282933) 1282933..1283646 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KWY74_RS06170 (1283669) 1283669..1284565 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KWY74_RS06175 (1284666) 1284666..1285187 + 522 WP_004144730.1 flavodoxin FldB -
KWY74_RS06180 (1285194) 1285194..1285604 - 411 WP_004181233.1 protein YgfX Toxin
KWY74_RS06185 (1285585) 1285585..1285851 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KWY74_RS06190 (1286097) 1286097..1287080 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KWY74_RS06195 (1287231) 1287231..1287890 - 660 WP_002916317.1 hemolysin III family protein -
KWY74_RS06200 (1288054) 1288054..1288365 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KWY74_RS06205 (1288415) 1288415..1289143 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KWY74_RS06210 (1289262) 1289262..1290695 + 1434 WP_004181234.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16121.92 Da        Isoelectric Point: 11.1565

>T209386 WP_004181233.1 NZ_CP079164:c1285604-1285194 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T209386 NZ_CP104077:267011-267118 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT209386 WP_002916312.1 NZ_CP079164:c1285851-1285585 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT209386 NZ_CP104077:c266962-266899 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATAACTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References