Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3433071..3433690 Replicon chromosome
Accession NZ_CP079155
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC08_CMC432MC

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KWY73_RS16505 Protein ID WP_002892050.1
Coordinates 3433071..3433289 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KWY73_RS16510 Protein ID WP_002892066.1
Coordinates 3433316..3433690 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWY73_RS16470 (3429118) 3429118..3429381 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
KWY73_RS16475 (3429381) 3429381..3429521 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KWY73_RS16480 (3429518) 3429518..3430216 - 699 WP_004178762.1 GNAT family protein -
KWY73_RS16485 (3430317) 3430317..3431768 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KWY73_RS16490 (3431743) 3431743..3432213 - 471 WP_002892026.1 YlaC family protein -
KWY73_RS16495 (3432234) 3432234..3432374 + 141 WP_004147370.1 hypothetical protein -
KWY73_RS16500 (3432346) 3432346..3432912 - 567 WP_002892030.1 maltose O-acetyltransferase -
KWY73_RS16505 (3433071) 3433071..3433289 - 219 WP_002892050.1 HHA domain-containing protein Toxin
KWY73_RS16510 (3433316) 3433316..3433690 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KWY73_RS16515 (3434176) 3434176..3437322 - 3147 WP_218389926.1 multidrug efflux RND transporter permease subunit AcrB -
KWY73_RS16520 (3437345) 3437345..3438538 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T209371 WP_002892050.1 NZ_CP079155:c3433289-3433071 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T209371 NZ_CP104049:3326450-3326977 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCATGGATTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGACACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCGGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT209371 WP_002892066.1 NZ_CP079155:c3433690-3433316 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT209371 NZ_CP104049:3326163-3326453 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References