Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 2838304..2839114 Replicon chromosome
Accession NZ_CP079155
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC08_CMC432MC

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag KWY73_RS13680 Protein ID WP_004178461.1
Coordinates 2838581..2839114 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag KWY73_RS13675 Protein ID WP_002887278.1
Coordinates 2838304..2838570 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWY73_RS13655 (2834176) 2834176..2834520 - 345 WP_004197273.1 cation efflux system protein CusF -
KWY73_RS13660 (2834538) 2834538..2835923 - 1386 WP_004178457.1 efflux transporter outer membrane subunit -
KWY73_RS13665 (2836095) 2836095..2836778 + 684 WP_002887273.1 copper response regulator transcription factor CusR -
KWY73_RS13670 (2836768) 2836768..2838201 + 1434 WP_004178459.1 Cu(+)/Ag(+) sensor histidine kinase -
KWY73_RS13675 (2838304) 2838304..2838570 + 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
KWY73_RS13680 (2838581) 2838581..2839114 + 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
KWY73_RS13685 (2839162) 2839162..2840283 - 1122 WP_002887282.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T209370 WP_004178461.1 NZ_CP079155:2838581-2839114 [Klebsiella pneumoniae subsp. pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T209370 NZ_CP104049:c2339183-2339080 [Salmonella enterica subsp. enterica serovar Kentucky]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT209370 WP_002887278.1 NZ_CP079155:2838304-2838570 [Klebsiella pneumoniae subsp. pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT209370 NZ_CP104049:2339078-2339221 [Salmonella enterica subsp. enterica serovar Kentucky]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References